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Disease X-19 News Review | ||
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Saved Stories - Disease X-19: Germany's Billionaire 'Sausage King' Faces Coronavirus Reckoning | ||
Sun, 28 Jun 2020 11:32:13 -0400 Germany's Billionaire 'Sausage King' Faces Coronavirus Reckoning ... for mayor of Rheda-Wiedenbrueck, where the shuttered pork plant is based. Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Coronavirus: Germans roast billionaire 'sausage king' as anger mounts over abattoir cluster | ||
Sun, 28 Jun 2020 11:32:01 -0400 Coronavirus: Germans roast billionaire 'sausage king' as anger mounts ... for mayor of Rheda-Wiedenbrueck, where the closed pork plant is based. Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Covid-19: Over 14% in Kolkata have coronavirus antibodies, finds seroprevalence survey by ICMR | ||
Sun, 28 Jun 2020 11:28:48 -0400 Antibody is a protective protein produced by the immune system in response to the presence of a foreign substance, an antigen. In this case it is the new ... Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - CoronaVirus as Biological Weapon: Biological Weapons Origin Control And Challenges | ||
Sun, 28 Jun 2020 11:26:35 -0400 Campaign for Universality and Implementation China s novel coronavirus epidemic could well become Xi Jinping s greatest internal challenge. This ... Google Alert - CoronaVirus as Biological Weapon Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - sars cov 2 as bioweapon: Why the Coronavirus Pandemic and America's Disastrous Response Will Inspire Future Use of ... | ||
Sun, 28 Jun 2020 11:23:58 -0400 Why the Coronavirus Pandemic and America's Disastrous Response Will Inspire Future Use of Bioweapons. June 26, 2020 Brian E. Frydenborg Leave a ... Google Alert - sars cov 2 as bioweapon Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - CoronaVirus as Biological Weapon: Download Biological War | ||
Sun, 28 Jun 2020 11:23:36 -0400 A biological weapon uses a bacteria or virus, or in some cases toxins that ... Biological Weapons And Biosecurity: Lessons From The COVID-19 War ... Google Alert - CoronaVirus as Biological Weapon Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - sars cov 2 as bioweapon: The Latest: South Korea still coping with new virus clusters | ||
Sun, 28 Jun 2020 11:23:12 -0400 Who wants to bet that all of the corona "hotspots" are in swing states? Convenient for Dems, huh? Susan Sprig 8 minutes ago. This bio-weapon, er, ... Google Alert - sars cov 2 as bioweapon Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - COVID-19 is used as a Bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | ||
Sun, 28 Jun 2020 11:22:51 -0400 The coronavirus is a genetically engineered bioweapon made by the ... The phrase 'rabbit hole' is often used in the context of conspiracy theories ... Google Alert - COVID-19 is used as a Bioweapon Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - sars cov 2 as bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | ||
Sun, 28 Jun 2020 11:22:40 -0400 The coronavirus is a genetically engineered bioweapon made by the Chinese. Or possibly the Americans. It originated in a lab in Wuhan. Or possibly ... Google Alert - sars cov 2 as bioweapon Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus criminal investigations: Kim Urges Police to Continue Fight against Organized Crime in Albania | ||
Sun, 28 Jun 2020 11:20:57 -0400 ... duties you have had recently in fighting the Coronavirus pandemic, you have continued to press forward with criminal investigations and policing. Google Alert - coronavirus criminal investigations Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Coronavirus and failure of US Intelligence Services: Trump denies briefing on reported bounties against US troops | ||
Sun, 28 Jun 2020 11:20:14 -0400 American intelligence officials concluded months ago that Russian officials ... Nobody's been tougher on Russia than the Trump Administration. ... in chief and his failure to protect U.S. troops in Afghanistan and stand up to Russia. ... Confirmed coronavirus cases hit 10 million worldwide; Pence skips ... Google Alert - Coronavirus and failure of US Intelligence Services Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: 28/06/20 09:02 from Disease X-19 from Michael_Novakhov (82 sites) The Barcelona COVID-19 discovery questions prevailing assumptions news.cgtn.com/news/2020-06-2 via @cgtnofficial Posted by mikenov on Sunday, June 28th, 2020 | ||
Sun, 28 Jun 2020 11:17:10 -0400
_____________________________________________________________________________ Disease X-19 News Review In Brief __________________________________________
» Saved Stories - Disease X-19: The Barcelona COVID-19 discovery questions prevailing assumptions news.cgtn.com/news/2020-06-2 via @cgtnofficial
28/06/20 09:02 from Disease X-19 from Michael_Novakhov (82 sites) The Barcelona COVID-19 discovery questions prevailing assumptions news.cgtn.com/news/2020-06-2 via @cgtnofficial Posted by mikenov on Sunday, June 28th, 2020 10:58am Saved Stories - Disease X-19
» Saved Stories - Disease X-19: This study suggests that the story behind COVID-19 may not be as clear or as simple as initially thought. Science must lead the way in determining its origin... The Barcelona COVID-19 discovery questions prevailing assumpti
28/06/20 09:02 from Disease X-19 from Michael_Novakhov (82 sites) This study suggests that the story behind COVID-19 may not be as clear or as simple as initially thought. Science must lead the way in determining its origin... The Barcelona COVID-19 discovery questions prevailing assumptions - CGTN new...
» Saved Stories - Disease X-19: Google Alert - Coronavirus in brooklyn: The Latest: Confirmed coronavirus cases pass 10 million
28/06/20 09:01 from Disease X-19 from Michael_Novakhov (82 sites) Confirmed coronavirus infections have surpassed the 10 million mark worldwide. A tally compiled by Johns Hopkins University registered the grim ... Google Alert - Coronavirus in brooklyn Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - coronavirus in israel: 'Coronavirus cabinet' meeting ends with no decision on new restrictions
28/06/20 09:01 from Disease X-19 from Michael_Novakhov (82 sites) ' Coronavirus cabinet' meeting ends with no decision on new restrictions ... The Times of Israel is liveblogging Sunday's events as they happen. Google Alert - coronavirus in israel Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - coronavirus vaccine: WHO chief hopeful of coronavirus vaccine within a year
28/06/20 09:01 from Disease X-19 from Michael_Novakhov (82 sites) Adhanom underlined the importance of global cooperation to develop, manufacture and distribute vaccines to curb the spread of coronavirus . Google Alert - coronavirus vaccine Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - coronavirus vaccine: Sinopharm Says Second Covid Vaccine Found to Be Safe
28/06/20 09:01 from Disease X-19 from Michael_Novakhov (82 sites) NOTE: June 23, Chinese Covid-19 Vaccines Cleared for Final Testing in U.A.E.; NOTE: June 17, Sinopharm Jumps Most in 5 Years on Coronavirus ... Google Alert - coronavirus vaccine Saved Stories - Disease X-19
» Saved Stories - Disease X-19: mikenov on Twitter: Barcelona COVID-19 wastewater study Google Search google.com/search?q=Barce
28/06/20 09:00 from Disease X-19 from Michael_Novakhov (82 sites) Barcelona COVID-19 wastewater study Google Search google.com/search?q=Barce Posted by mikenov on Sunday, June 28th, 2020 11:23am mikenov on Twitter Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Barcelona COVID-19 wastewater study - Google Search google.com/search?q=Barce
28/06/20 08:59 from Disease X-19 from Michael_Novakhov (82 sites) Barcelona COVID-19 wastewater study - Google Search google.com/search?q=Barce Posted by mikenov on Sunday, June 28th, 2020 11:23am Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - covid-19 in meat plants workers: The Virus Is Changing How We Eat
28/06/20 08:59 from Disease X-19 from Michael_Novakhov (82 sites) Many Germans were already eating less meat before Covid - 19 forced ... of workers testing positive and plant shutdowns spurring temporary meat ... Google Alert - covid-19 in meat plants workers Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - covid-19 in meat plants workers: Immigrant labor has fueled meatpacking industry since its earliest days in Nebraska
28/06/20 08:59 from Disease X-19 from Michael_Novakhov (82 sites) Since the first cattle shuffled off of a railcar at the Omaha stockyards in the 1880s, headed for ... Then, in March, COVID - 19 hit meatpacking plants hard. Google Alert - covid-19 in meat plants workers Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - Covid-19: Genetic factors: 2 Top Gene-Editing Stocks to Buy Right Now
28/06/20 08:58 from Disease X-19 from Michael_Novakhov (82 sites) Uncertainty tied to the unprecedented coronavirus disease 2019 ( COVID - 19 ) pandemic initially sent the benchmark S&P 500 screaming lower by 34% ... Google Alert - Covid-19: Genetic factors Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - coronavirus on twitter: Coronavirus, BLM protest conspiracy theories collide on Facebook and Twitter
28/06/20 08:58 from Disease X-19 from Michael_Novakhov (82 sites) CNET also found dozens of posts on Facebook, Instagram and Twitter that include false claims about both the coronavirus and the Black Lives Matter ... Google Alert - coronavirus on twitter Saved Stories - Disease X-19
» Saved Stories - Disease X-19: Google Alert - Coronavirus and white supremacy: Post Premium: Our best stories for the week of June 22-28
28/06/20 08:58 from Disease X-19 from Michael_Novakhov (82 sites) The shutdown brought by the fight against coronavirus didn't stop artists ... up against formidable forces of white supremacy and a global pandemic? Google Alert - Coronavirus and white supremacy Saved Stories - Disease X-19
» Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - Sars-Cov-2 in Livestock: Vets and medics team up to provide Covid tests
28/06/20 08:56 from Disease X-19 from Michael_Novakhov (82 sites) ... of livestock over the years. Together with our collaborators at SRUC, we have combined facilities and skills to extend capacity of Covid-19 during the ... Google Alert - Sars-Cov-2 in Livestock Disease X-19 Epidemiology from Mic... Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: 28/06/20 05:11 from Disease X-19 from Michael_Novakhov (82 sites) According to statistics published by the Russian Ministry of Health, the daily gain of patients with COVID-19 in Russia by early June varied in the range | ||
Sun, 28 Jun 2020 11:16:58 -0400
_____________________________________________________________________________ Disease X-19 News Review In Brief __________________________________________
» Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus statistics: Official Numbers Still Low, But Russian System Feeling COVID's Stress
28/06/20 05:11 from Disease X-19 from Michael_Novakhov (82 sites) According to statistics published by the Russian Ministry of Health, the daily gain of patients with COVID-19 in Russia by early June varied in the range ... Google Alert - coronavirus statistics Disease X-19 Epidemiology from Micha...
» Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus epidemiology: China places half a million in lockdown near Beijing over new Covid-19 cases
28/06/20 05:00 from Disease X-19 from Michael_Novakhov (82 sites) Now, only one person from each family will be allowed to go out once a day to purchase necessities such as food and medicine, the county's epidemic ... Google Alert - coronavirus epidemiology Disease X-19 Epidemiology from Michael_...
» Disease X-19 and Security from Michael_Novakhov (10 sites): Google Alert - Coronavirus and US Navy: Different but challenging: Naval Academy prepares for Induction Day and Plebe Summer
28/06/20 05:00 from Disease X-19 from Michael_Novakhov (82 sites) What that will allow us to do is to ensure that there's not going to be spread ... This is based off of modeling looking at the spread of the coronavirus . Google Alert - Coronavirus and US Navy Disease X-19 and Security from Michael_No...
» Disease X-19 and Security from Michael_Novakhov (10 sites): Google Alert - coronavirus criminal investigations: Kuwait parliament asks why Eurofighter deal is so expensive
28/06/20 05:00 from Disease X-19 from Michael_Novakhov (82 sites) Kuwait in recent years initiated criminal investigations into two large military ... "Suicide cases have started to go up in Kuwait during the coronavirus ... Google Alert - coronavirus criminal investigations Disease X-19 and...
» Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus epidemiology: Indonesia reports 1198 coronavirus cases, 34 new deaths
28/06/20 04:48 from Disease X-19 from Michael_Novakhov (82 sites) JAKARTA: Indonesia reported 1,198 new coronavirus cases and 34 deaths on ... But Wu Zunyou, chief epidemiology expert at the Chinese Center for ... Google Alert - coronavirus epidemiology Disease X-19 Epidemiology from Michael_Novak...
» Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in israel: Fearing spike in corona cases as borders reopen, EU excludes Israel from travel list
28/06/20 04:37 from Disease X-19 from Michael_Novakhov (82 sites) French daily Le Monde names Israel , US, Russia, Turkey, and Saudi Arabia as countries the EU considers as having a troubling coronavirus infection ... Google Alert - coronavirus in israel Disease X-19 Regions from Michael_Novakhov ... Saved Stories - Disease X-19 | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - coronavirus pulmonary symptoms: I wasn't dying - I was just misusing a pulse oximeter | ||
Sun, 28 Jun 2020 11:00:00 -0400 ... lower-than-healthy level of oxygen saturation in the blood can be an early predictor of covid-related pneumonia, even in those with mild symptoms. Google Alert - coronavirus pulmonary symptoms Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Saved Stories - Disease X-19: Google Alert - covid-19 in meat plants: Germany: Gütersloh slaughterhouse infections spread to community | ||
Sun, 28 Jun 2020 10:52:41 -0400 There has been a "noticeable" increase in the number of coronavirus ... the employees and associates of the Tönnies meat processing plant, however, ... Google Alert - covid-19 in meat plants Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - covid-19 neurological symptoms: Coronavirus updates: Cases surpass 10 million worldwide; viral video shows confrontation over ... | ||
Sun, 28 Jun 2020 10:52:09 -0400 As confirmed coronavirus cases across the globe exceeded 10 million early ... COVID-19 diagnosis and a new neurological or psychiatric diagnosis. Google Alert - covid-19 neurological symptoms Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus herd immunity: The race to find a COVID-19 vaccine | ||
Sun, 28 Jun 2020 10:51:37 -0400 "Its objective is to finish developing, and then to manufacture and distribute, a proven coronavirus vaccine as fast as possible," he said. "Again, we'd ... Google Alert - coronavirus herd immunity Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus in israel: Ministry of Health: 6160 active coronavirus patients in Israel | ||
Sun, 28 Jun 2020 10:51:03 -0400 45 patients are in serious condition, of which 24 require respiratory aid via ventilators. Two people died from the virus in the past day, bringing Israel's ... Google Alert - coronavirus in israel Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus epidemiology: No mathematical model correctly predicted future course of Covid-19 so far: ICMR chief | ||
Sun, 28 Jun 2020 10:50:40 -0400 With July arriving soon, it's imperative to consider how some government models that the epidemic in India will be over by September. Some ... Google Alert - coronavirus epidemiology Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Sars-Cov-2 origins: The Barcelona COVID-19 discovery questions prevailing assumptions | ||
Sun, 28 Jun 2020 10:50:00 -0400
The precise origin of COVID-19 is not scientifically certain. What experts know is that the genome behind the virus is of a zoonotic origin, which at ... Google Alert - Sars-Cov-2 origins Saved Stories - Disease X-19 | ||
Disease X-19 and Security from Michael_Novakhov (10 sites): Google Alert - Coronavirus and US Military: 06/28/2020 News & Commentary Korea | ||
Sun, 28 Jun 2020 10:37:30 -0400 10. US Forces Korea eases anti-coronavirus restrictions for Yongsan Garrison. 11. Time to End America's 70 Year War with North Korea. 12. N. Korea ... Google Alert - Coronavirus and US Military Disease X-19 and Security from Michael_Novakhov (10 sites) | ||
Saved Stories - Disease X-19: Google Alert - Sars-Cov-2 origins: Lubbock ends week with most new coronavirus cases | ||
Sun, 28 Jun 2020 09:54:10 -0400 As of Saturday, the origin of 506 cases remains under investigation, according to the health department. There were 43 people with coronavirus ... Google Alert - Sars-Cov-2 origins Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Coronavirus on Yahoo News: Brazil coronavirus cases rise past 1.3m | ||
Sun, 28 Jun 2020 09:53:48 -0400 There are thousands of news cases and hundreds of deaths every day and the crisis is not yet thought to be at its peak. Brazil has the second-highest ... Google Alert - Coronavirus on Yahoo News Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv: Nowcasting the COVID-19 Pandemic in Bavaria | ||
Sun, 28 Jun 2020 09:47:03 -0400 To assess the current dynamic of an epidemic it is central to collect information on the daily number of newly diseased cases. This is especially important in real-time surveillance, when one aims at evaluating the effects of interventions on disease spread. Reporting delays between disease onset and case reporting hamper our ability to understand the dynamic of an epidemic when looking at the number of daily reported cases only. Nowcasting can be used to adjust daily case counts for occurred-but-not-yet-reported events. Here, we present a novel application of nowcasting to data on the current COVID-19 pandemic in Bavaria. It is based on a hierarchical Bayesian model that considers changes in the reporting delay distribution associated with the week and weekday of reporting and assumes a smooth epidemic curve. Furthermore, we present a way to estimate the time-dependent case reproduction number R(t) based on predictions of the nowcast. We provide methodological details of the developed approach, illustrate results based on data of the current epidemic, discuss limitations and alternative estimation strategies, and provide code for reproduction or adaption of the nowcasting to data from different regions. Results of the nowcasting approach are reported to the Bavarian health authority and published on a webpage on a daily basis. Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv: Secondary pneumonia in critically ill ventilated patients with COVID-19 | ||
Sun, 28 Jun 2020 09:46:26 -0400 Background Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) for invasive artificial ventilation and are at significant risk of developing a secondary, ventilator-associated pneumonia (VAP). Objectives To study the incidence of VAP, as well as differences in secondary infections, and bacterial lung microbiome composition of ventilated COVID-19 and non-COVID-19 patients. Methods In this prospective observational study, we compared the incidence of VAP and secondary infections using a combination of a TaqMan multi-pathogen array and microbial culture. In addition, we determined the lung microbime composition using 16S RNA analyisis. The study involved eighteen COVID-19 and seven non-COVID-19 patients receiving invasive ventilation in three ICUs located in a single University teaching hospital between April 13th 2020 and May 7th 2020. Results We observed a higher percentage of confirmed VAP in COVID-19 patients. However, there was no statistical difference in the detected organisms or pulmonary microbiome when compared to non-COVID-19 patients. Conclusion COVID-19 makes people more susceptible to developing VAP, partly but not entirely due to the increased duration of ventilation. The pulmonary dysbiosis caused by COVID-19, and the array of secondary infections observed are similar to that seen in critically ill patients ventilated for other reasons. Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv: Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population | ||
Sun, 28 Jun 2020 09:46:02 -0400 Convalescent plasma is currently one of the leading treatments for COVID-19, but there is a paucity of data identifying therapeutic efficacy. A comprehensive analysis of the antibody responses in potential plasma donors and an understanding of the clinical and demographic factors that drive variant antibody responses is needed. Among 126 potential convalescent plasma donors, the humoral immune response was evaluated by a SARS-CoV-2 virus neutralization assay using Vero-E6-TMPRSS2 cells, commercial IgG and IgA ELISA to Spike (S) protein S1 domain (Euroimmun), IgA, IgG and IgM indirect ELISAs to the full-length S or S-receptor binding domain (S-RBD), and an IgG avidity assay. Multiple linear regression and predictive models were utilized to assess the correlations between antibody responses with demographic and clinical characteristics. IgG titers were greater than either IgM or IgA for S1, full length S, and S-RBD in the overall population. Of the 126 plasma samples, 101 (80%) had detectable neutralizing titers. Using neutralization titer as the reference, the sensitivity of the IgG ELISAs ranged between 95-98%, but specificity was only 20-32%. Male sex, older age, and hospitalization with COVID-19 were all consistently associated with increased antibody responses across the serological assays. Neutralizing antibody titers were reduced over time in contrast to overall antibody responses. There was substantial heterogeneity in the antibody response among potential convalescent plasma donors, but sex, age and hospitalization emerged as factors that can be used to identify individuals with a high likelihood of having strong antiviral antibody levels. Collection : COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus: Global coronavirus death toll nears 500000: Live updates | ||
Sun, 28 Jun 2020 09:44:02 -0400 Brazil recorded 38,693 new cases of the novel coronavirus in the past 24 hours and 1,109 additional deaths, the Health Ministry said. The nation has ... Google Alert - coronavirus Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Coronavirus and HIV: Country's third oldest LGBTQ newspaper Seattle Gay News at risk of shutting down | ||
Sun, 28 Jun 2020 09:43:31 -0400 ... HIV/AIDS funding and most recently Referendum 74 for marriage equality ... As the coronavirus pandemic hit small businesses hard, ad space isn't ... Google Alert - Coronavirus and HIV Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Coronavirus and cyber attacks: Four ways you can ensure cyber safety while working from home | ||
Sun, 28 Jun 2020 09:43:07 -0400 ... to the Cyber Threat Report by K7 Security, cyber-attacks, including phishing emails and fake apps, jumped by 260 percent during the coronavirus ... Google Alert - Coronavirus and cyber attacks Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus in israel: Nationwide Serological Testing to Begin on Sunday | ||
Sun, 28 Jun 2020 09:42:04 -0400 Israel's health-care system is set to begin nationwide serological testing on ... In contrast to the test for the coronavirus itself, which is based on nasal ... Google Alert - coronavirus in israel Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Coronavirus and failure of US Intelligence Services: The Harsh Truths Coronavirus Has Exposed | ||
Sun, 28 Jun 2020 09:39:59 -0400 " George Packer, We Are Living in a Failed State/Underlying Conditions, The ... the U.S. coronavirus response makes it look like like a third-world country. ... The company was drastically overcharging for the masks and the items ... Google Alert - Coronavirus and failure of US Intelligence Services Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus cardiac symptoms: More evidence emerges that coronavirus entered through LAX | ||
Sun, 28 Jun 2020 09:39:46 -0400 Since then, the risk of asymptomatic people has become clear. ... 68-year-old woman who had symptoms before the trip and suffered cardiac arrest the ... Google Alert - coronavirus cardiac symptoms Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus in israel: COVID-19 cases, deaths mount in Middle East | ||
Sun, 28 Jun 2020 09:39:15 -0400 Iraq, Saudi Arabia, Israel report additional infections, fatalities. Ali Semerci, Sofya Hocabasi and Mustafa Deveci | 28.06.2020. COVID-19 ... Google Alert - coronavirus in israel Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - new york times on coronavirus: Asia Today: South Korea Reports 62 New Cases, China Has 17 | ||
Sun, 28 Jun 2020 09:39:02 -0400 SEOUL, South Korea South Korea has confirmed 62 additional cases of the coronavirus over a 24-hour period, as the country continues to grapple ... Google Alert - new york times on coronavirus Saved Stories - Disease X-19 | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - covid-19 in meat plants: Two more Covid-19 deaths announced in Wales as localised outbreaks are investigated | ||
Sun, 28 Jun 2020 09:30:00 -0400 Investigations are also ongoing at the site of a meat processing site in Merthyr. Promoted Stories. New coronavirus cases reported in Wales today. Most ... Google Alert - covid-19 in meat plants Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Saved Stories - Disease X-19: Google Alert - coronavirus outbreak: Baltimore resuming sanitation services after COVID outbreak | ||
Sun, 28 Jun 2020 09:28:37 -0400 BALTIMORE Baltimore's trash and recycling collection services, which had been impacted by a COVID-19 outbreak among sanitation workers, will ... Google Alert - coronavirus outbreak Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - new york times on coronavirus: Germany's Confirmed Coronavirus Cases Rise by 256 to 193499: RKI | ||
Sun, 28 Jun 2020 09:28:26 -0400 BERLIN The number of confirmed coronavirus cases in Germany increased by 256 to 193,499, data from the Robert Koch Institute (RKI) for ... Google Alert - new york times on coronavirus Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus epidemiology: 5 ways the world is better off dealing with a pandemic now than in 1918 | ||
Sun, 28 Jun 2020 09:28:02 -0400 By contrast, the world has been able to track this epidemic in real-time, and scientists have quickly ... Doctors didn't yet know influenza viruses existed. Google Alert - coronavirus epidemiology Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Covid-19: genetic studies: Reverse Zoonosis When Humans Pass Diseases on to Animals | ||
Sun, 28 Jun 2020 09:27:36 -0400 ... zoonosis is the possible transmission of the novel coronavirus from humans ... Based on further genetic studies, they were able to conclude that the ... Google Alert - Covid-19: genetic studies Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - covid-19 superspreaders: Nightclub 'superspreader' leads to several infections and 300 people isolated | ||
Sun, 28 Jun 2020 09:27:01 -0400 In a statement, the health department spoke of its first-ever COVID-19 "superspreader" event. Initially, one man who had visited the club tested positive ... Google Alert - covid-19 superspreaders Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: The Barcelona COVID-19 discovery questions prevailing assumptions news.cgtn.com/news/2020-06-2 via @cgtnofficial | ||
Sun, 28 Jun 2020 09:02:37 -0400
The Barcelona COVID-19 discovery questions prevailing assumptions news.cgtn.com/news/2020-06-2 via @cgtnofficial
Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: This study suggests that the story behind COVID-19 may not be as clear or as simple as initially thought. Science must lead the way in determining its origin... The Barcelona COVID-19 discovery questions prevailing assumpti | ||
Sun, 28 Jun 2020 09:02:14 -0400
This study suggests that the story behind COVID-19 may not be as clear or as simple as initially thought. Science must lead the way in determining its origin...
The Barcelona COVID-19 discovery questions prevailing assumptions - CGTN news.cgtn.com/news/2020-06-2 Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - Coronavirus in brooklyn: The Latest: Confirmed coronavirus cases pass 10 million | ||
Sun, 28 Jun 2020 09:01:40 -0400 Confirmed coronavirus infections have surpassed the 10 million mark worldwide. A tally compiled by Johns Hopkins University registered the grim ... Google Alert - Coronavirus in brooklyn Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus in israel: 'Coronavirus cabinet' meeting ends with no decision on new restrictions | ||
Sun, 28 Jun 2020 09:01:28 -0400 'Coronavirus cabinet' meeting ends with no decision on new restrictions ... The Times of Israel is liveblogging Sunday's events as they happen. Google Alert - coronavirus in israel Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus vaccine: WHO chief hopeful of coronavirus vaccine within a year | ||
Sun, 28 Jun 2020 09:01:17 -0400 Adhanom underlined the importance of global cooperation to develop, manufacture and distribute vaccines to curb the spread of coronavirus. Google Alert - coronavirus vaccine Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - coronavirus vaccine: Sinopharm Says Second Covid Vaccine Found to Be Safe | ||
Sun, 28 Jun 2020 09:01:05 -0400 NOTE: June 23, Chinese Covid-19 Vaccines Cleared for Final Testing in U.A.E.; NOTE: June 17, Sinopharm Jumps Most in 5 Years on Coronavirus ... Google Alert - coronavirus vaccine Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: mikenov on Twitter: Barcelona COVID-19 wastewater study Google Search google.com/search?q=Barce | ||
Sun, 28 Jun 2020 09:00:19 -0400
mikenov on Twitter
Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Barcelona COVID-19 wastewater study - Google Search google.com/search?q=Barce | ||
Sun, 28 Jun 2020 08:59:54 -0400 Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - covid-19 in meat plants workers: The Virus Is Changing How We Eat | ||
Sun, 28 Jun 2020 08:59:43 -0400 Many Germans were already eating less meat before Covid-19 forced ... of workers testing positive and plant shutdowns spurring temporary meat ... Google Alert - covid-19 in meat plants workers Saved Stories - Disease X-19 | ||
Saved Stories - Disease X-19: Google Alert - covid-19 in meat plants workers: Immigrant labor has fueled meatpacking industry since its earliest days in Nebraska | ||
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Sun, 28 Jun 2020 04:48:45 -0400 JAKARTA: Indonesia reported 1,198 new coronavirus cases and 34 deaths on ... But Wu Zunyou, chief epidemiology expert at the Chinese Center for ... Google Alert - coronavirus epidemiology Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
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Sun, 28 Jun 2020 04:26:15 -0400 Prime Minister Benjamin Netanyahu said Sunday that Israel's coronavirus cabinet, tasked with leading the government's response to the virus ... Google Alert - coronavirus in israel Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
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Sun, 28 Jun 2020 04:26:15 -0400 Landowners would move to either scale up eco-tourism on their land or change their land use from hunting to domestic livestock farming. A trophy ... Google Alert - Sars-Cov-2 in Livestock Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
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Sun, 28 Jun 2020 04:26:15 -0400 Sweden is much worse than Portugal, with a two-week rate of 111.7 cars per 100,000. The country took a herd immunity approach to the virus and it ... Google Alert - sweden herd immunity Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
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mikenov on Twitter: May 19, 2020 - New study finds evidence of a sign of human intervention in COVID-19 ... The team led by Nikolai Petrovsky Coronavirus is 'Perfectly Adapted' to Infect Humans Raising Petrovsky study of Sars-Cov-2 - Google Search goo | ||
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Sat, 27 Jun 2020 14:45:29 -0400
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Sat, 27 Jun 2020 14:45:00 -0400 Canada has pledged $120 million CAD for the ACT-Accelerator, and $180 million CAD for COVID-19 humanitarian and development aid. Google Alert - Coronavirus and HIV Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
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mikenov on Twitter: Russia denies allegation that it offered bounties to militants in Afghanistan for killing American troops twitter.com/i/events/12768 | ||
Sat, 27 Jun 2020 14:34:16 -0400
Russia denies allegation that it offered bounties to militants in Afghanistan for killing American troops twitter.com/i/events/12768
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Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: Russia denies allegation that it offered bounties to militants in Afghanistan for killing American troops twitter.com/i/events/12768 | ||
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Russia denies allegation that it offered bounties to militants in Afghanistan for killing American troops twitter.com/i/events/12768…
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Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - covid-19 in meat plants workers: Tyson Foods says 371 additional workers have tested positive for COVID-19 at Missouri chicken ... | ||
Sat, 27 Jun 2020 12:30:00 -0400 Tyson Foods announced Friday that 371 employees at its chicken plant in Noel, Missouri had tested positive for COVID-19. Friday's announcement ... Google Alert - covid-19 in meat plants workers Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - coronavirus cardiac symptoms: Milton Glaser, designer of 'I LOVE NY' logo is no more | ||
Sat, 27 Jun 2020 12:30:00 -0400 The cause was a stroke and Glaser had also had renal failure, his wife, ... AAP's Sanjay Singh; Amit Shah, Kejriwal visit biggest COVID-19 centre in Delhi ... patient therefore his cardiac catheterisation/coronary intervention had been ... Google Alert - coronavirus cardiac symptoms Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - Coronavirus by country, ethnicity, and race: Arizona coronavirus update: 70051 confirmed cases, 1579 known deaths as of Saturday | ||
Sat, 27 Jun 2020 12:30:00 -0400 Arizona cases of COVID-19, the disease caused by the new coronavirus, now exceed ... as Arizona deals with one of the worst spikes of COVID-19 in the country. ... While race/ethnicity is unknown for 45% of cases, 25% of cases are ... Google Alert - Coronavirus by country, ethnicity, and race Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus antibodies test: In Simi Valley, people line up for antibody tests out of curiosity, hope for peace of mind | ||
Sat, 27 Jun 2020 12:30:00 -0400 The testing is part of a larger COVID-19 antibody study offered by a ... pretty early for coronavirus, but I was pretty curious just to get the antibody test to ... Google Alert - coronavirus antibodies test Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
mikenov on Twitter: SARS-CoV-2 has been evolving for at least 7 years news-medical.net/news/20200625/ | ||
Sat, 27 Jun 2020 12:26:50 -0400 mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: SARS-CoV-2 has been evolving for at least 7 years news-medical.net/news/20200625/ | ||
Sat, 27 Jun 2020 12:26:50 -0400
SARS-CoV-2 has been evolving for at least 7 years news-medical.net/news/20200625/…
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Michael Novakhov - SharedNewsLinks: SARS-CoV-2 has been evolving for at least 7 years | ||
Sat, 27 Jun 2020 12:26:25 -0400
The current COVID-19 pandemic demonstrates the vast unknown of virology, which continues to challenge the ability of humanity to remain healthy when faced with pathogens. While most known microbes have restricted affinity for specific species, continuing to adapt with the host species, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has crossed over from an unknown animal reservoir, like the preceding SARS and MERS coronaviruses, to infect human cells. Such viruses are typically more readily infective and cause more severe disease, as they have not yet adapted fully to the target host.
Novel Coronavirus SARS-CoV-2 Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID
Acquiring Potential for Human InfectionThe burning question is how novel viruses acquire the ability to recognize, bind to and enter human cells for the first time whether this is dependent only on viral proteins recognizing host cell proteins, or adaptations in other viral processes that allow replication in a human host.This issue is discussed by researchers at the University of Calgary in a new study published on the preprint server bioRxiv* in June 2020. The spike protein is the most well known of the SARS-CoV-2 proteins, and its binding to ACE2 receptors on the host cell is responsible for viral entry into the target cell. The human ACE2 (hACE2) has some rare variants which make the host more vulnerable to infection. Similarly, the spike protein of this virus has a greater affinity for the receptor than the previous SARS virus, which is another possible explanation for the increased infective potential of the current virus. The Study: Origin of ACE2 Binding AffinityThe current study examines the origin of this spike protein variant with its affinity for hACE2, using molecular dynamics (MD) simulations along with sequence reconstruction to identify the adaptation pathway of the virus. The result is a preliminary phylogenetic analysis that agrees with earlier studies the virus is 96% similar to the bat coronavirus (RaTG13) genome and 90% similar to the Pangolin-CoV genome.The next step was to carry out a more detailed analysis of 479 sequences collected from December 30, 2019, to March 20, 2020, where they found 16 variants. Of these, 11 were missense mutations occurring in 5% or more of cases, and each had its own phylogenetic route. The researchers then tried to recreate the ancestral sequence for the spike-RBD region, so that they could identify the important mutations that specifically drive its recent adaptation to the human host. They reconstructed the hypothetical common ancestor spike-RBD sequence for all human SARS-CoV-2 cases, called N1, and for the common ancestor with the closest animal virus, called N2. N1 is identical to the sequence in the SARS-CoV-2 reference sequence, but the N0 sequence is unique, which shows that this virus has originated uniquely. The two differ at 4 positions. The ancestral protein gave rise to various descendants, one of which is the RaTG13. Since this was around in 2013, the researchers conclude that the ancestral strain existed as early as that year, at least. In other words, the N0-N1 branch has been evolving for at least 7 years. Ancestral Sequence Had Higher Binding AffinityWhat are the functional differences between N0 and current spike-RBD sequences? The researchers used MD simulations of the spike-RBD-hACE2 complex, beginning with the X-ray crystal structures. The model showed that the free binding energy for this complex decreased as N0 changed to N1. Thus, this actually reduced the binding affinity both in the simulations and in vitro.However, two of the changes were associated with more significant decreases than the other. This shows that the N0 strain had, unexpectedly, greater binding affinity than the N1 strain. This is the first study to show that the common ancestor of both SARS-CoV-2 and the RaTG13 had the ability to bind to the ACE2 receptor in humans. Other Molecular Changes Key to InfectivityThe implications are that firstly, the binding affinity of the spike-RBD to hACE2 is not the primary driver of the highly infectious nature of the current virus since the ancestral virus was capable of doing this too. Secondly, the researchers suggest that this virus was, even then, able to bind tightly to the receptor. Therefore, this was not sufficient to produce the currently observed ability to spread rapidly and widely among humans. Instead, this must be due to another set of mutations in the viral genome.Yet another implication is that the current virus may not have jumped to humans from an animal origin at all because its affinity for hACE2 was not a recently acquired molecular trait. This may mean that the ability to infect human cells was present over a more extended period in the past, but produced less obvious or fewer clinical symptoms which passed unnoticed. Another alternative was that it affected only a small number of people, allowing it to remain under the public health radar.
Characterization of SARS-CoV-2 Spike-RBD functional evolution. A. Table of MM/PBSA binding energies between receptor binding domains of SARS-CoV2 evolutionary constructs and hACE2 receptor (note that lower energy indicates tighter binding). Blue cells indicate the presence of the ancestral (N0) state and green cells (with an x) indicate the presence of the SARS-CoV-2 state (N1) at a given position. Two values are present for constructs with an ancestral (N0) state at position 498 (which reflect the ambiguity of its ancestral reconstruction), corresponding to h498 and y498 from left to right. Energies are shown as the mean of three replicate simulations with SEM indicated in parenthesis. B. The relative effect of changes in the SARS-CoV-2 receptor-binding domain from ancestral (N0) to SARS-CoV-2 (N1) state on MM/PBSA binding energies. Size of spheres indicates the relative magnitude, with red spheres indicating decreased binding affinity and blue indicating increased binding affinity. Values are averaged for h498 and y498 states (both raw values shown in parentheses). C. Schematic of two possible evolutionary scenarios stemming from the observed evolutionary SARS-CoV-2 Spike-RBD function. In Scenario 1, it is postulated that a zoonotic ancestral SARS-CoV-2 strain possessed the ability to effectively bind hACE2 but was unable to effectively enter human cells, requiring the presence of subsequent mutations to infect humans. In Scenario 2, an ancestral SARS-CoV-2 strain was actively infecting humans prior to the outbreak at low levels, thus escaping public health detection until subsequent mutations lead to increased infectivity and/or severity.
Future ResearchThese possibilities can only be tested by a broad-spectrum approach to sequencing all coronavirus strains in human populations, as this will reveal the presence of closely related viruses if such are present.The current study is an in silico study, and further validation of these findings is necessary using combinatorial libraries which can be screened to map functionalities to the genomic regions of the virus. This will help understand how the virus evolved in the most recent past. The researchers conclude: It appears that the SARS-CoV-2 Spike-RBD did not recently evolve binding affinity to a human-specific protein. Instead, that function appears to have been latent, making it clear that the evolution of this disease along with so many other aspects of its etiology is more complex than expected. *Important NoticebioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.Michael Novakhov - SharedNewsLinks | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - Coronavirus and skin: Arizona tops 70000 cases of COVID-19, with 1579 deaths | ||
Sat, 27 Jun 2020 12:18:45 -0400 Arizona has added 3,591 cases and 44 deaths of COVID-19 overnight, ... Taking new clients + Minted Skin Care Peoria Minted Skin Care is an ... Google Alert - Coronavirus and skin Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in italy: Schools in Italy scheduled to reopen on Sept. 14 | ||
Sat, 27 Jun 2020 12:18:45 -0400 Where it stands: COVID-19 infections and fatalities have remained low in Italy throughout June after a steady decrease in May, per data from the World ... Google Alert - coronavirus in italy Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus statistics: Coronavirus policies should be informed by 'the numbers': Steve Ballmer | ||
Sat, 27 Jun 2020 11:56:15 -0400 " From a USAFacts perspective, we hope they make them well-informed with the numbers, what really happened, and do they need to change course, ... Google Alert - coronavirus statistics Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - coronavirus cardiac symptoms: Montana State football player reported positive for coronavirus | ||
Sat, 27 Jun 2020 11:56:15 -0400 The athletes in these cases must undergo cardiac evaluation before any ... Athletes were also asked to self-monitor possible symptoms and to stay ... Google Alert - coronavirus cardiac symptoms Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus new york: Reopen NY: Potential COVID-19 exposure at Westchester County high school graduation, health ... | ||
Sat, 27 Jun 2020 11:56:15 -0400 CHAPPAQUA, New York (WABC) -- New York State's Department of Health is investigating the potential COVID-19 exposure at a high school ... Google Alert - coronavirus new york Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - saliva coronavirus test: We can beat England in their own backyard: Pak captain Ali | ||
Sat, 27 Jun 2020 11:56:11 -0400 The first Test begins at Lord's on July 30, and the team leaves for the tour on ... Operating Procedures for bowlers because of the COVID-19 pandemic. ... in English conditions and not being able to use saliva means our bowlers can ... Google Alert - saliva coronavirus test Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
mikenov on Twitter: Dermatologists question link between COVID toes and coronavirus cases - Business Insider businessinsider.com/covid-toes-pur | ||
Sat, 27 Jun 2020 11:48:38 -0400
Dermatologists question link between COVID toes and coronavirus cases - Business Insider businessinsider.com/covid-toes-pur
mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: Dermatologists question link between COVID toes and coronavirus cases Business Insider businessinsider.com/covid-toes-pur | ||
Sat, 27 Jun 2020 11:48:38 -0400
Dermatologists question link between COVID toes and coronavirus cases – Business Insider businessinsider.com/covid-toes-pur…
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Michael Novakhov - SharedNewsLinks: Disease X-19 News Review In Brief - 11:41 AM 6/27/2020: SARS-CoV-2 has been evolving for at least 7 years | ||
Sat, 27 Jun 2020 11:46:35 -0400
Disease X-19 News Review In Brief - 11:41 AM 6/27/2020
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» Michael Novakhov - SharedNewsLinks: 9:42 AM 6/27/2020 - SARS-CoV-2 has been evolving for at least 7 years: "We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBDs functiona
27/06/20 10:25 from Disease X-19 from Michael_Novakhov (82 sites) Michael_Novakhov shared this story from Covid-19-Review. 9:42 AM 6/27/2020 "We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBDs functional evolution, fi...
» Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus in blacks: Funeralizing a community, again
27/06/20 09:30 from Disease X-19 from Michael_Novakhov (82 sites) The coronavirus , the virus that causes the deadly illness called COVID -19, eerily ... The COVID -19 data on race has revealed that black and brown ... Google Alert - coronavirus in blacks Disease X-19 Epidemiology from Michael_Nov... Michael Novakhov - SharedNewsLinks | ||
mikenov on Twitter: RT @NYPDShea: As we talk about increases in gun violence & crime overall, we have to remember that were also talking about increases in th | ||
Sat, 27 Jun 2020 11:45:37 -0400
As we talk about increases in gun violence & crime overall, we have to remember that were also talking about increases in the number of real people who instantly become victims.
These are NYers whos lives may be forever changedor in some casesended. foxnews.com/media/nypd-chi
Retweeted by mikenov on Saturday, June 27th, 2020 3:45pm
55 likes, 16 retweets mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @NYPDShea: As we talk about increases in gun violence & crime overall, we have to remember that were also talking about increases in th | ||
Sat, 27 Jun 2020 11:45:37 -0400
As we talk about increases in gun violence & crime overall, we have to remember that we’re also talking about increases in the number of real people who instantly become victims.
These are NYers who’s lives may be forever changed—or in some cases—ended. foxnews.com/media/nypd-chi…
34 likes, 12 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @JuliaDavisNews: Russian Info Ops Putting US Police in Their Crosshairs: Russia, through the English-language RT, is reaching out to U. | ||
Sat, 27 Jun 2020 11:45:24 -0400
Russian Info Ops Putting US Police in Their Crosshairs:
Russia, through the English-language RT, is reaching out to U.S. police officers and union officials, in what some U.S. officials and lawmakers say is an effort to further inflame tensions. voanews.com/usa/russian-in
Retweeted by mikenov on Saturday, June 27th, 2020 3:45pm
543 likes, 553 retweets mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @JuliaDavisNews: Russian Info Ops Putting US Police in Their Crosshairs: Russia, through the English-language RT, is reaching out to U. | ||
Sat, 27 Jun 2020 11:45:24 -0400
Russian Info Ops Putting US Police in Their Crosshairs:
Russia, through the English-language RT, is reaching out to U.S. police officers and union officials, in what some U.S. officials and lawmakers say is an effort to further inflame tensions. voanews.com/usa/russian-in…
242 likes, 250 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @PressTV: Bill Gates: COVID-19 'will be back in big numbers' in October-November #coronavirus presstv.com/Detail/2020/06 | ||
Sat, 27 Jun 2020 11:45:10 -0400
Bill Gates: COVID-19 'will be back in big numbers' in October-November
#coronavirus presstv.com/Detail/2020/06
Retweeted by mikenov on Saturday, June 27th, 2020 3:45pm
66 likes, 31 retweets mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @PressTV: Bill Gates: COVID-19 will be back in big numbers in October-November #coronavirus presstv.com/Detail/2020/06 | ||
Sat, 27 Jun 2020 11:45:10 -0400
Bill Gates: COVID-19 ‘will be back in big numbers’ in October-November
#coronavirus presstv.com/Detail/2020/06…
46 likes, 22 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - saliva coronavirus test: Coronavirus Or Flu? Scientists Are Developing A Sensor Which Tests For Both Simultaneously | ||
Sat, 27 Jun 2020 11:45:00 -0400 Because the test is to be conducted at home, the researchers imagine the test would be most easily conducted through the analysis of a sample of saliva ... Google Alert - saliva coronavirus test Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - Coronavirus and pet food: ECOLOGIC: But wait there's more | ||
Sat, 27 Jun 2020 11:45:00 -0400 With COVID-19 raging around the globe, the public, media, and medical ... of whooping cough in Nunavut and a massive recall of pet food that caused E. ... on the disease through their milka whole new food hazard for humans. Google Alert - Coronavirus and pet food Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - Coronavirus and skin: Latest News 2020: Skin Packaging Materials Market analysis by COVID19 Impact Analysis With ... | ||
Sat, 27 Jun 2020 11:45:00 -0400 Latest News 2020: Skin Packaging Materials Market analysis by COVID19 Impact Analysis With Top Manufacturers Analysis | Top Players: Sealed Air ... Google Alert - Coronavirus and skin Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in africa: How Covid-19 has upended the South African alcohol industry | ||
Sat, 27 Jun 2020 11:45:00 -0400 With sales growing 50% year to year, South Africa's gin industry was booming before the country instated a strict ban on the production, sale, and ... Google Alert - coronavirus in africa Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 and Security from Michael_Novakhov (10 sites): Google Alert - Coronavirus and US Military: You Won't Believe How Many Airlines Haven't Survived Coronavirus. How Does It Affect You? | ||
Sat, 27 Jun 2020 11:45:00 -0400 There has even been talk of American Airlines' demise. ... passenger flights for cruise operators, professional sports teams, the US military and more. Google Alert - Coronavirus and US Military Disease X-19 and Security from Michael_Novakhov (10 sites) | ||
Michael Novakhov - SharedNewsLinks: Disease X-19 News Review In Brief - 10:58 AM 6/27/2020: » mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks | ||
Sat, 27 Jun 2020 11:04:00 -0400
_____________________________________________________________________________ 10:58 AM 6/27/2020 Disease X-19 News Review In Brief __________________________________________
» mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c
27/06/20 06:51 from Disease X-19 from Michael_Novakhov (82 sites) SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c Posted by mikenov on Saturday, June 27th, 2020 10:51am mikenov on Twitter
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c
27/06/20 06:51 from Disease X-19 from Michael_Novakhov (82 sites) SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c Posted by mikenov on Saturday, June 27th, 2020 10:51am mikenov on Twitter Covid-19 Review: The Pandem...
» mikenov on Twitter: RT @EpochOpinion: Opinion
27/06/20 06:45 from Disease X-19 from Michael_Novakhov (82 sites) Opinion | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Michael Novakhov SharedNewsLinks: Disease X-19 News Review In Brief 10:58 AM 6/27/2020: » mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Netwo | ||
Sat, 27 Jun 2020 11:04:00 -0400
_____________________________________________________________________________ 10:58 AM 6/27/2020 Disease X-19 News Review In Brief __________________________________________
» mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c…
27/06/20 06:51 from Disease X-19 from Michael_Novakhov (82 sites) SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c… Posted by mikenov on Saturday, June 27th, 2020 10:51am mikenov on Twitter
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c…
27/06/20 06:51 from Disease X-19 from Michael_Novakhov (82 sites) SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c… Posted by mikenov on Saturday, June 27th, 2020 10:51am mikenov on Twitter Covid-19 Review: The Pandem…
» mikenov on Twitter: RT @EpochOpinion: Opinion
27/06/20 06:45 from Disease X-19 from Michael_Novakhov (82 sites) Opinion
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @EpochOpinion: Opinion
27/06/20 06:45 from Disease X-19 from Michael_Novakhov (82 sites) OpinionðŸ’by Brian Cates @drawandstrike New documents revealed a bombshell: both President @BarackObama and VP @JoeBiden were directly involved in the @FBI’s investigation of @GenFlynn. These notes demonstrate that #Obama and…
» mikenov on Twitter: RT @DailyMailUK: Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd Posted by DailyMailUK on Saturday, June 27th, 2020 10:21am Retweeted by mikenov on Saturday, June 27th, 2020 10:44am 58 lik…
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @DailyMailUK: Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd Posted by DailyMailUK on Saturday, June 27th, 2020 10:21am Retweeted by mikenov on Saturday, June 27th, 2020 10…
» mikenov on Twitter: RT @KremlinTrolls: THREAD: How @realDonaldTrump became Putin’s most valuable asset:mobile.twitter.com/KremlinTrolls/…
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) THREAD: How @realDonaldTrump became Putin’s most valuable asset: mobile.twitter.com/KremlinTrolls/… In 1987 Trump ran $130k of full page ads aggressively attacking NATO. And he did that during the cold war, right after returning from Mos…
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @KremlinTrolls: THREAD: How @realDonaldTrump became Putin’s most valuable asset:mobile.twitter.com/KremlinTrolls/…
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) THREAD: How @realDonaldTrump became Putin’s most valuable asset: mobile.twitter.com/KremlinTrolls/… In 1987 Trump ran $130k of full page ads aggressively attacking NATO. And he did that during the cold war, right after retur…
» mikenov on Twitter: RT @NYPDDCPI: NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipet…
27/06/20 06:43 from Disease X-19 from Michael_Novakhov (82 sites) NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipetri discusses where the increase in gun violence originates and what can be done to end it. Watch more via @FoxNews
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @NYPDDCPI: NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipet…
27/06/20 06:43 from Disease X-19 from Michael_Novakhov (82 sites) NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipetri discusses where the increase in gun violence originates and what can be done to end it. Watch more via @FoxNe…
» mikenov on Twitter: RT @QuizGriz: Fishermen Spot Animal Stuck On Iceberg. They Get Closer and Freeze When They See What It Really Is.
27/06/20 06:42 from Disease X-19 from Michael_Novakhov (82 sites) Fishermen Spot Animal Stuck On Iceberg. They Get Closer and Freeze When They See What It Really Is.
» mikenov on Twitter: Germany Coronavirus Outbreak: Meat Plant Triggers Cases – Bloomberg bloomberg.com/news/articles/…
27/06/20 06:42 from Disease X-19 from Michael_Novakhov (82 sites) Germany Coronavirus Outbreak: Meat Plant Triggers Cases – Bloomberg bloomberg.com/news/articles/… Posted by mikenov on Saturday, June 27th, 2020 10:42am mikenov on Twitter Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Covid-19-Review: Disease X-19 News Review In Brief 10:58 AM 6/27/2020: » mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks | ||
Sat, 27 Jun 2020 11:01:40 -0400 _____________________________________________________________________________ 10:58 AM 6/27/2020 Disease X-19 News Review In Brief __________________________________________
» mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c…
27/06/20 06:51 from Disease X-19 from Michael_Novakhov (82 sites) SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c… Posted by mikenov on Saturday, June 27th, 2020 10:51am mikenov on Twitter
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c…
27/06/20 06:51 from Disease X-19 from Michael_Novakhov (82 sites) SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c… Posted by mikenov on Saturday, June 27th, 2020 10:51am mikenov on Twitter Covid-19 Review: The Pandem…
» mikenov on Twitter: RT @EpochOpinion: Opinion
27/06/20 06:45 from Disease X-19 from Michael_Novakhov (82 sites) Opinion
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @EpochOpinion: Opinion
27/06/20 06:45 from Disease X-19 from Michael_Novakhov (82 sites) OpinionðŸ’by Brian Cates @drawandstrike New documents revealed a bombshell: both President @BarackObama and VP @JoeBiden were directly involved in the @FBI’s investigation of @GenFlynn. These notes demonstrate that #Obama and…
» mikenov on Twitter: RT @DailyMailUK: Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd Posted by DailyMailUK on Saturday, June 27th, 2020 10:21am Retweeted by mikenov on Saturday, June 27th, 2020 10:44am 58 lik…
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @DailyMailUK: Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd Posted by DailyMailUK on Saturday, June 27th, 2020 10:21am Retweeted by mikenov on Saturday, June 27th, 2020 10…
» mikenov on Twitter: RT @KremlinTrolls: THREAD: How @realDonaldTrump became Putin’s most valuable asset:mobile.twitter.com/KremlinTrolls/…
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) THREAD: How @realDonaldTrump became Putin’s most valuable asset: mobile.twitter.com/KremlinTrolls/… In 1987 Trump ran $130k of full page ads aggressively attacking NATO. And he did that during the cold war, right after returning from Mos…
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @KremlinTrolls: THREAD: How @realDonaldTrump became Putin’s most valuable asset:mobile.twitter.com/KremlinTrolls/…
27/06/20 06:44 from Disease X-19 from Michael_Novakhov (82 sites) THREAD: How @realDonaldTrump became Putin’s most valuable asset: mobile.twitter.com/KremlinTrolls/… In 1987 Trump ran $130k of full page ads aggressively attacking NATO. And he did that during the cold war, right after retur…
» mikenov on Twitter: RT @NYPDDCPI: NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipet…
27/06/20 06:43 from Disease X-19 from Michael_Novakhov (82 sites) NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipetri discusses where the increase in gun violence originates and what can be done to end it. Watch more via @FoxNews
» Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @NYPDDCPI: NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipet…
27/06/20 06:43 from Disease X-19 from Michael_Novakhov (82 sites) NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipetri discusses where the increase in gun violence originates and what can be done to end it. Watch more via @FoxNe…
» mikenov on Twitter: RT @QuizGriz: Fishermen Spot Animal Stuck On Iceberg. They Get Closer and Freeze When They See What It Really Is.
27/06/20 06:42 from Disease X-19 from Michael_Novakhov (82 sites) Fishermen Spot Animal Stuck On Iceberg. They Get Closer and Freeze When They See What It Really Is.
» mikenov on Twitter: Germany Coronavirus Outbreak: Meat Plant Triggers Cases – Bloomberg bloomberg.com/news/articles/…
27/06/20 06:42 from Disease X-19 from Michael_Novakhov (82 sites) Germany Coronavirus Outbreak: Meat Plant Triggers Cases – Bloomberg bloomberg.com/news/articles/… Posted by mikenov on Saturday, June 27th, 2020 10:42am mikenov on Twitter
» Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert – coronavirus in iran: Coronavirus Cases in Iran Surpass 220000
27/06/20 06:30 from Disease X-19 from Michael_Novakhov (82 sites) Speaking at a daily press conference on Saturday, Sima Sadat Lari said the number of people tested positive for COVID-19 across the country has risen … Google Alert – coronavirus in iran Disease X-19 Regions from Michael_Novakhov …
» Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert – coronavirus in iran: Iran reveals COVID-19 statistics for June 27
27/06/20 06:30 from Disease X-19 from Michael_Novakhov (82 sites) By Elnur Baghishov – Trend: As many as 2,456 people have been infected with the coronavirus ( COVID-19 ) in the past 24 hours in Iran , said Sima Sadat … Google Alert – coronavirus in iran Disease X-19 Regions from Michael_Novakho…
» mikenov on Twitter: Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought – The New York Times nytimes.com/2020/06/26/hea…
27/06/20 06:19 from Disease X-19 from Michael_Novakhov (82 sites) Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought – The New York Times nytimes.com/2020/06/26/hea… Posted by mikenov on Saturday, June 27th, 2020 10:19am mikenov on Twitter
» mikenov on Twitter: Covid-19-Review: Coronavirus and US Military: As COVID-19 spikes across US, troop diagnoses jump 20 percent in a week | Coronavirus and HIV: How the Coronavirus Short-Circuits the Immune System covid-19-review.blogspot.com/2020/06/556-
27/06/20 06:15 from Disease X-19 from Michael_Novakhov (82 sites) Covid-19-Review: Coronavirus and US Military: As COVID-19 spikes across US, troop diagnoses jump 20 percent in a week | Coronavirus and HIV: How the Coronavirus Short-Circuits the Immune System covid-19-review.blogspot.com/2020/06/556-am… | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus in animals: New Centre County shop caters to pets and owners, with adoption opportunities in the works | ||
Sat, 27 Jun 2020 10:37:30 -0400 Opening during the coronavirus pandemic, she said, provided an easy and ... They're very caring, understanding and patient with the animals (and) ... Google Alert - coronavirus in animals Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 and Security from Michael_Novakhov (10 sites): Google Alert - Coronavirus and US Military: 'I still have nightmares every night' health workers struggle with PTSD symptoms as coronavirus ... | ||
Sat, 27 Jun 2020 10:30:24 -0400 Many have witnessed more death than soldiers during war with the coronavirus taking more than 120,000 lives in the U.S. alone. Anyone experiencing ... Google Alert - Coronavirus and US Military Disease X-19 and Security from Michael_Novakhov (10 sites) | ||
Michael Novakhov - SharedNewsLinks: 9:42 AM 6/27/2020 - SARS-CoV-2 has been evolving for at least 7 years: "We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBDs functiona | ||
Sat, 27 Jun 2020 10:25:50 -0400
9:42 AM 6/27/2020 "We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBDs functional evolution, finding to our surprise that it has likely possessed high affinity for human cell targets since at least 2013." Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
Erin Brintnell, Mehul Gupta, Dave W Anderson
doi: <a href="https://doi.org/10.1101/2020.06.22.165787" rel="nofollow">https://doi.org/10.1101/2020.06.22.165787</a>
_____________________________________________________________________
This article is a preprint and has not been certified by peer review [what does this mean?].
SARS-CoV-2 has been evolving for at least 7 years https://news.knowledia.com/AU/en/articles/sars-cov-2-has-been-evolving-for-at-least-7-years-a376631e4f1f43879dbf4720405fc94a26b7eafe
SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks
Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought - The New York Times https://www.nytimes.com/2020/06/26/health/coronavirus-spain.html
Michael Novakhov - SharedNewsLinks | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Michael Novakhov SharedNewsLinks: 9:42 AM 6/27/2020 SARS-CoV-2 has been evolving for at least 7 years: We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dyn | ||
Sat, 27 Jun 2020 10:25:50 -0400
9:42 AM 6/27/2020 “We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBD’s functional evolution, finding to our surprise that it has likely possessed high affinity for human cell targets since at least 2013.” Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
Erin Brintnell, Mehul Gupta, Dave W Anderson
doi: <a href=”https://doi.org/10.1101/2020.06.22.165787″ rel=”nofollow”>https://doi.org/10.1101/2020.06.22.165787</a>
_____________________________________________________________________
This article is a preprint and has not been certified by peer review [what does this mean?].
SARS-CoV-2 has been evolving for at least 7 years https://news.knowledia.com/AU/en/articles/sars-cov-2-has-been-evolving-for-at-least-7-years-a376631e4f1f43879dbf4720405fc94a26b7eafe …
SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks
Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought – The New York Times https://www.nytimes.com/2020/06/26/health/coronavirus-spain.html …
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Google Alert sars cov 2 as bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | ||
Sat, 27 Jun 2020 10:21:00 -0400
The coronavirus is a genetically engineered bioweapon made by the Chinese. Or possibly the Americans. It originated in a lab in Wuhan. Or possibly …
Google Alert – sars cov 2 as bioweapon Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Google Alert COVID-19 is used as a Bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | ||
Sat, 27 Jun 2020 10:20:56 -0400
The coronavirus is a genetically engineered bioweapon made by the … The phrase ‘rabbit hole’ is often used in the context of conspiracy theories …
Google Alert – COVID-19 is used as a Bioweapon Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Google Alert sars cov 2 as bioweapon: Bagley: Making better greetings | ||
Sat, 27 Jun 2020 10:20:54 -0400
Everyone is looking forward to the COVID-19 pandemic ending. … us handshakes can kill, that as one epidemiologist has said, they are “bio-weapons.
Google Alert – sars cov 2 as bioweapon Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - covid-19 superspreaders: Americans confront 'very scary' next phase of coronavirus pandemic as new infections spike across ... | ||
Sat, 27 Jun 2020 10:15:00 -0400 Calling the recent surge in coronavirus cases in states like Florida, Texas ... getting together and creating what we call superspreader events, Patel ... Google Alert - covid-19 superspreaders Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in israel: Israeli researchers find ibuprofen doesn't aggravate COVID-19 infection | ||
Sat, 27 Jun 2020 10:15:00 -0400 An Israeli research team has found that ibuprofen does not aggravate symptoms caused by the coronavirus. This comes after the reigning controversy ... Google Alert - coronavirus in israel Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Covid-19-Review: 9:42 AM 6/27/2020 SARS-CoV-2 has been evolving for at least 7 years: We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to | ||
Sat, 27 Jun 2020 10:14:50 -0400 9:42 AM 6/27/2020 “We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBD’s functional evolution, finding to our surprise that it has likely possessed high affinity for human cell targets since at least 2013.” Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
Erin Brintnell, Mehul Gupta, Dave W Anderson
doi: https://doi.org/10.1101/2020.06.22.165787
_____________________________________________________________________
This article is a preprint and has not been certified by peer review [what does this mean?].
SARS-CoV-2 has been evolving for at least 7 years https://news.knowledia.com/AU/en/articles/sars-cov-2-has-been-evolving-for-at-least-7-years-a376631e4f1f43879dbf4720405fc94a26b7eafe …
SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks
Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought – The New York Times https://www.nytimes.com/2020/06/26/health/coronavirus-spain.html …
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Sat, 27 Jun 2020 10:03:45 -0400 With coronavirus outbreaks continuing to spread across the world, the United States is "likely" to see a shortage of generic pharmaceutical drugs, ... Google Alert - coronavirus outbreak Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Origins from Michael_Novakhov (3 sites): Google Alert - coronavirus origins: New research offers details about the mysterious 'COVID toes' symptom but raises questions, too | ||
Sat, 27 Jun 2020 09:52:30 -0400 "Dermatologists must be aware of the protean cutaneous findings that are possibly associated with COVID-19, even if our understanding of their origins ... Google Alert - coronavirus origins Disease X-19 Origins from Michael_Novakhov (3 sites) | ||
Disease X-19 Publications from Michael_Novakhov (5 sites): Google Alert - covid-19 in daily mail: Americans shouldn't flee for the suburbs to get away from COVID-19 as study finds DENSER US ... | ||
Sat, 27 Jun 2020 09:52:30 -0400 Americans living in dense cities are not causing the bulk of COVID-19 infections to rise and are not contributing to as many deaths, according to a new ... Google Alert - covid-19 in daily mail Disease X-19 Publications from Michael_Novakhov (5 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - Coronavirus in brooklyn: The Latest: German leader urges caution as economy opens | ||
Sat, 27 Jun 2020 09:52:30 -0400 By The Associated Press. BERLIN - German Chancellor Angela Merkel cautioned Saturday that the coronavirus pandemic is far from over, as regional ... Google Alert - Coronavirus in brooklyn Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in italy: Italy records 30 new COVID-19 deaths, 16 from Lombardy | ||
Sat, 27 Jun 2020 09:52:30 -0400 Rome, Jun 27 (AP) Italy registered 30 more deaths of people with coronavirus infections on Friday, with 16 of them in Lombardy, the northern region ... Google Alert - coronavirus in italy Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in israel: Teflon Thailand is primed for Israeli innovation solutions | ||
Sat, 27 Jun 2020 09:41:15 -0400 So much so, that he believes even the coronavirus (Covid-19) pandemic will ... Thai companies were regularly visiting Israel prior to Covid-19 to learn ... Google Alert - coronavirus in israel Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus in blacks: Funeralizing a community, again | ||
Sat, 27 Jun 2020 09:30:00 -0400 The coronavirus, the virus that causes the deadly illness called COVID-19, eerily ... The COVID-19 data on race has revealed that black and brown ... Google Alert - coronavirus in blacks Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - Covid-19 blood clots: New COVID-19 Discoveries Made By Tampa Bay Area Scientists | ||
Sat, 27 Jun 2020 09:30:00 -0400 Heart illnesses, blood illnesses, blood clotting, liver injury, kidney injury, neurological injury, said Dr. Thogmartin. But one thing he says hasn't changed ... Google Alert - Covid-19 blood clots Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Publications from Michael_Novakhov (5 sites): Google Alert - coronavirus in new york post: Increased restaurant spending linked to rise in coronavirus, study says | ||
Sat, 27 Jun 2020 09:30:00 -0400 Sign up for our special edition newsletter to get a daily update on the coronavirus pandemic. Your favorite restaurant food may be coming with a side of ... Google Alert - coronavirus in new york post Disease X-19 Publications from Michael_Novakhov (5 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - Covid-19 blood clots: New research offers details about the mysterious 'COVID toes' symptom but raises questions, too | ||
Sat, 27 Jun 2020 09:18:45 -0400 But a growing number of coronavirus patients have displayed similar ... They might also result from blood clots in skin vessels, or a combination of all ... Google Alert - Covid-19 blood clots Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - Coronavirus and skin: New research offers details about the mysterious 'COVID toes' symptom but raises questions, too | ||
Sat, 27 Jun 2020 09:18:45 -0400 On average, patients in their study developed skin lesions around nine days after their first coronavirus symptoms arrived. For now, the link between " ... Google Alert - Coronavirus and skin Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Publications from Michael_Novakhov (5 sites): Google Alert - coronavirus in new york post: Rashid Brimmage was lost in perfect storm of coronavirus chaos, city incompetence | ||
Sat, 27 Jun 2020 09:18:45 -0400 Rashid Brimmage was lost in perfect storm of coronavirus chaos, city ... For 15 years, New York City has failed Rashid Brimmage and the people he ... cleared out and so they weren't able to reach him at that time, Khan said. Google Alert - coronavirus in new york post Disease X-19 Publications from Michael_Novakhov (5 sites) | ||
Disease X-19 Publications from Michael_Novakhov (5 sites): Google Alert - covid-19 in daily mail: Britain announces 84 more Covid-19 deaths in preliminary toll - taking the total number of ... | ||
Sat, 27 Jun 2020 09:10:45 -0400 Preliminary death figure is calculated by adding up coronavirus deaths across the UK over the last 24 hours; But it does not take into account fatalities ... Google Alert - covid-19 in daily mail Disease X-19 Publications from Michael_Novakhov (5 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - Coronavirus, subway, and MTA: Opinion: Local Control of the MTA is About Equity and Efficiency | ||
Sat, 27 Jun 2020 09:07:30 -0400 The MTA, historically, has been an organization rooted in systemic inequality ... Reducing this inefficiency by restructuring the Metropolitan Transit Authority ... by years of mismanagement but now exacerbated by the COVID-19 crisis. Google Alert - Coronavirus, subway, and MTA Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in israel: US company with Israeli roots to test COVID-19 vaccine on humans by August | ||
Sat, 27 Jun 2020 09:07:30 -0400 A California company with Israeli roots said its animal studies of a potential novel coronavirus vaccine are so promising that they believe they can ... Google Alert - coronavirus in israel Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Publications from Michael_Novakhov (5 sites): Google Alert - coronavirus in new york post: DOE refuses to reveal number of teachers, school workers sickened by coronavirus | ||
Sat, 27 Jun 2020 09:07:25 -0400 " They absolutely should be tracking Covid cases among the staff, and ... Kruppa battled the coronavirus for 80 days before succumbing on June 20, her ... subject, and the endless love and care you showed for all your students. The DOE and City Hall have ignored repeated requests by The Post for the ... Google Alert - coronavirus in new york post Disease X-19 Publications from Michael_Novakhov (5 sites) | ||
Michael Novakhov - SharedNewsLinks: SARS-CoV-2 has been evolving for at least 7 years | ||
Sat, 27 Jun 2020 09:06:02 -0400
<a href="http://www.news-medical.net" rel="nofollow">www.news-medical.net</a>
The burning question is how novel viruses acquire the ability to recognize, bind to and enter human cells for the first time whether this is dependent only on viral proteins recognizing host cell proteins, or adaptations in other viral processes that allow replication in a human host.The current COVID-19 pandemic demonstrates the vast unknown of virology, which continues to challenge the ability of humanity to remain healthy when faced with pathogens. While most known microbes have restricted affinity for specific species, continuing to adapt with the host species, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has crossed over from an unknown animal reservoir, like the preceding SARS and MERS coronaviruses, to infect human cells. Such viruses are typically more readily infective and cause more severe disease, as they have not yet adapted fully to the target host. Novel Coronavirus SARS-CoV-2 Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Acquiring Potential for Human Infection This issue is discussed by researchers at the University of Calgary in a new study published on the preprint server bioRxiv* in June 2020. The spike protein is the most well known of the SARS-CoV-2 proteins, and its binding to ACE2 receptors on the host cell is responsible for viral entry into the target cell. The human ACE2 (hACE2) has some rare variants which make the host more vulnerable to infection. Similarly, the spike protein of this virus has a greater affinity for the receptor than the previous SARS virus, which is another possible explanation for the increased infective potential of the current virus. The Study: Origin of ACE2 Binding Affinity The current study examines the origin of this spike protein variant with its affinity for hACE2, using molecular dynamics (MD) simulations along with sequence reconstruction to identify the adaptation pathway of the virus. The result is a preliminary phylogenetic analysis that agrees with earlier studies the virus is 96% similar to the bat coronavirus (RaTG13) genome and 90% similar to the Pangolin-CoV genome. The next step was to carry out a more detailed analysis of 479 sequences collected from December 30, 2019, to March 20, 2020, where they found 16 variants. Of these, 11 were missense mutations occurring in 5% or more of cases, and each had its own phylogenetic route. The researchers then tried to recreate the ancestral sequence for the spike-RBD region, so that they could identify the important mutations that specifically drive its recent adaptation to the human host. They reconstructed the hypothetical common ancestor spike-RBD sequence for all human SARS-CoV-2 cases, called N1, and for the common ancestor with the closest animal virus, called N2. N1 is identical to the sequence in the SARS-CoV-2 reference sequence, but the N0 sequence is unique, which shows that this virus has originated uniquely. The two differ at 4 positions. The ancestral protein gave rise to various descendants, one of which is the RaTG13. Since this was around in 2013, the researchers conclude that the ancestral strain existed as early as that year, at least. In other words, the N0-N1 branch has been evolving for at least 7 years. Ancestral Sequence Had Higher Binding Affinity What are the functional differences between N0 and current spike-RBD sequences? The researchers used MD simulations of the spike-RBD-hACE2 complex, beginning with the X-ray crystal structures. The model showed that the free binding energy for this complex decreased as N0 changed to N1. Thus, this actually reduced the binding affinity both in the simulations and in vitro. However, two of the changes were associated with more significant decreases than the other. This shows that the N0 strain had, unexpectedly, greater binding affinity than the N1 strain. This is the first study to show that the common ancestor of both SARS-CoV-2 and the RaTG13 Read full article Michael Novakhov - SharedNewsLinks | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: Michael Novakhov SharedNewsLinks: SARS-CoV-2 has been evolving for at least 7 years | ||
Sat, 27 Jun 2020 09:06:02 -0400
<a href=”http://www.news-medical.net” rel=”nofollow”>www.news-medical.net</a> The current COVID-19 pandemic demonstrates the vast unknown of virology, which continues to challenge the ability of humanity to remain healthy when faced with pathogens. While most known microbes have restricted affinity for specific species, continuing to adapt with the host species, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has crossed over from an unknown animal reservoir, like the preceding SARS and MERS coronaviruses, to infect human cells. Such viruses are typically more readily infective and cause more severe disease, as they have not yet adapted fully to the target host. Novel Coronavirus SARS-CoV-2 Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (purple), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Acquiring Potential for Human Infection This issue is discussed by researchers at the University of Calgary in a new study published on the preprint server bioRxiv* in June 2020. The spike protein is the most well known of the SARS-CoV-2 proteins, and its binding to ACE2 receptors on the host cell is responsible for viral entry into the target cell. The human ACE2 (hACE2) has some rare variants which make the host more vulnerable to infection. Similarly, the spike protein of this virus has a greater affinity for the receptor than the previous SARS virus, which is another possible explanation for the increased infective potential of the current virus. The Study: Origin of ACE2 Binding Affinity The current study examines the origin of this spike protein variant with its affinity for hACE2, using molecular dynamics (MD) simulations along with sequence reconstruction to identify the adaptation pathway of the virus. The result is a preliminary phylogenetic analysis that agrees with earlier studies – the virus is 96% similar to the bat coronavirus (RaTG13) genome and 90% similar to the Pangolin-CoV genome. The next step was to carry out a more detailed analysis of 479 sequences collected from December 30, 2019, to March 20, 2020, where they found 16 variants. Of these, 11 were missense mutations occurring in 5% or more of cases, and each had its own phylogenetic route. The researchers then tried to recreate the ancestral sequence for the spike-RBD region, so that they could identify the important mutations that specifically drive its recent adaptation to the human host. They reconstructed the hypothetical common ancestor spike-RBD sequence for all human SARS-CoV-2 cases, called N1, and for the common ancestor with the closest animal virus, called N2. N1 is identical to the sequence in the SARS-CoV-2 reference sequence, but the N0 sequence is unique, which shows that this virus has originated uniquely. The two differ at 4 positions. The ancestral protein gave rise to various descendants, one of which is the RaTG13. Since this was around in 2013, the researchers conclude that the ancestral strain existed as early as that year, at least. In other words, the N0-N1 branch has been evolving for at least 7 years. Ancestral Sequence Had Higher Binding Affinity What are the functional differences between N0 and current spike-RBD sequences? The researchers used MD simulations of the spike-RBD-hACE2 complex, beginning with the X-ray crystal structures. The model showed that the free binding energy for this complex decreased as N0 changed to N1. Thus, this actually reduced the binding affinity both in the simulations and in vitro. However, two of the changes were associated with more significant decreases than the other. This shows that the N0 strain had, unexpectedly, greater binding affinity than the N1 strain. This is the first study to show that the common ancestor of both SARS-CoV-2 and the RaTG13… Read full article Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
Michael Novakhov - SharedNewsLinks: Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor | bioRxiv | ||
Sat, 27 Jun 2020 08:58:38 -0400
Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
Erin Brintnell, Mehul Gupta, Dave W Anderson
doi: <a href="https://doi.org/10.1101/2020.06.22.165787" rel="nofollow">https://doi.org/10.1101/2020.06.22.165787</a>
This article is a preprint and has not been certified by peer review [what does this mean?].
AbstractSARS-CoV-2 is a once-in-a-century pandemic, having emerged suddenly as a highly infectious viral pathogen. Previous phylogenetic analyses show its closest known evolutionary relative to be a virus isolated from bats (RaTG13), with a common assumption that SARS-CoV-2 evolved from a zoonotic ancestor via recent genetic changes (likely in the Spike protein receptor binding domain or RBD) that enabled it to infect humans. We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBDs functional evolution, finding to our surprise that it has likely possessed high affinity for human cell targets since at least 2013.Main TextViral pathogens are a continuous and evolving challenge for human populations.1,2 Most known viruses maintain species-specific infectivity, often co-evolving with their host to mirror animal species trees.3,4 While less common, the emergence of novel viral pathogens is of particular interest because they often exhibit abnormal degrees of infectivity and/or virulence,5 having not evolved to a natural selection balance with their new host.6 Viruses of animal origin include periodic Ebola outbreaks,7 the 1918 Spanish Flu,8 and most recently, SARS-CoV-2, the viral agent that causes COVID-19.9 In these cases, viruses spread through human populations after evolving to cross the species barrier.10 Yet, many questions remain for viruses of non-human origin: How do they acquire the ability to infect humans? Is it wholly dependent on recognition (a function typically mediated by protein-protein binding between viral capsid and target host cell), or must there be changes in other viral replication mechanisms as well? And specifically focusing on SARS-Cov-2, did it evolve to infect humans via many evolutionary changes or only a few? Was it dependent on a key functional shift in its ability to bind human cells, or is there evidence that other genomic changes were needed for it to acquire its strikingly high degree of infectivity? Answering these questions is critical if we are to understand both the origin of specific viruses, such as SARS-CoV-2, as well as the capacity of animal viruses to evolve human infectivity.SARS-CoV-2 emerged in late 201911 and has high infectivity, spreading rapidly around the world, causing a global health emergency.12 A member of the Coronaviridae family of polymorphic, enveloped, single stranded RNA viruses,13 it is thought that SARS-CoV-2 evolved from a zoonotic origin,14,15 owing to its clear evolutionary relationship with coronaviruses that have been isolated from animals16 (its closest known evolutionary relative is the bat coronavirus, RaTG131720 and the second-closest known relative is a pangolin coronavirus, Pangolin-CoV).21 While most of the SARS-CoV-2 genome is most similar to the RaTG13 genome, some genomic regions, including the Spike glycoprotein Receptor Binding Domain (RBD) (which mediates viral entry into host cells), have greater sequence similarity to the Pangolin-CoV homolog,22 prompting some to suggest SARS-CoV-2 may be the product of recombination during co-infection.2124 The Spike protein is a key component of the SARS-CoV-2 infection pathway.25 Knockout and overexpression studies have demonstrated that binding of the Spike-RBD to human angiotensin converting enzyme 2 (hACE2) mediates cellular entry of SARS-CoV-2.2630 The protein sequence of this surface receptor is variable, with particular rare variants increasing patient susceptibility to SARS-CoV-2 infection.31 The SARS-CoV-2 Spike protein has been shown to bind the hACE2 receptor with greater affinity than the SARS-CoV-1 homolog, which has been suggested as a possible explanation for its greater infectivity.29 Additionally, many other related coronaviruses have been shown to be unable to bind hACE2 with sufficient affinity to support infection, raising the possibility that high hACE2 is a recently acquired trait for SARS-CoV-2.3234 Given this, a critical question remains to be answered: How and when did the SARS-CoV-2 Spike protein evolve its relatively higher affinity for the hACE2? With this question in mind, we set out to robustly characterize the evolutionary changes that accompanied the emergence of SARS-CoV-2, and that distinguish it from its closest zoonotic relatives. We focused on the evolution of the Spike-RBD by leveraging its known evolutionary relationships to other animal and human viruses and employed ancestral sequence reconstruction in conjunction with molecular dynamics simulations to identify biochemical and biophysical changes that enhanced Spike binding to the hACE2 receptor. Our initial phylogenetic analysis utilized whole viral genomic data, and generally supports prior studies conclusions, finding similar levels of nucleotide identity to the RaTG13 genome (96.0% sequence identity) and the Pangolin-CoV genome (90.0% sequence identity) (Supplementary Figure 1A).21,29 We next quantified the degree of evolutionary diversification that has occurred during SARS-CoV-2s global spread. We performed an in-depth analysis of 479 sequences collected between December 30, 2019 and March 20, 2020, and observe 16 polymorphisms, including 11 missense mutations present in >5% of infections (Supplemental Table 1), each mapping to unique phylogenetic branches (Figure 1A). One monophyletic clade was primarily isolated within the United States and Canada, and is defined by two synapomorphic missense mutations: c.17848A>G and c.28134C>T.35 Since these occur in one of the most variable parts of the coronavirus genome, it is likely that its distribution is due to a founder effect and that it does not confer an evolutionary advantage.36 It is also worth noting that neither appears in the Spike protein-coding region, making it unlikely to impact hACE2 affinity. | ||
Sat, 27 Jun 2020 08:58:38 -0400
Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
Erin Brintnell, Mehul Gupta, Dave W Anderson
doi: <a href=”https://doi.org/10.1101/2020.06.22.165787″ rel=”nofollow”>https://doi.org/10.1101/2020.06.22.165787</a>
This article is a preprint and has not been certified by peer review [what does this mean?].
AbstractSARS-CoV-2 is a once-in-a-century pandemic, having emerged suddenly as a highly infectious viral pathogen. Previous phylogenetic analyses show its closest known evolutionary relative to be a virus isolated from bats (RaTG13), with a common assumption that SARS-CoV-2 evolved from a zoonotic ancestor via recent genetic changes (likely in the Spike protein receptor binding domain – or RBD) that enabled it to infect humans. We used detailed phylogenetic analysis, ancestral sequence reconstruction, and molecular dynamics simulations to examine the Spike-RBD’s functional evolution, finding to our surprise that it has likely possessed high affinity for human cell targets since at least 2013.Main TextViral pathogens are a continuous and evolving challenge for human populations.1,2 Most known viruses maintain species-specific infectivity, often co-evolving with their host to mirror animal species trees.3,4 While less common, the emergence of novel viral pathogens is of particular interest because they often exhibit abnormal degrees of infectivity and/or virulence,5 having not evolved to a natural selection balance with their new host.6 Viruses of animal origin include periodic Ebola outbreaks,7 the 1918 “Spanish Flu”,8 and most recently, SARS-CoV-2, the viral agent that causes COVID-19.9 In these cases, viruses spread through human populations after evolving to “cross the species barrier”.10 Yet, many questions remain for viruses of non-human origin: How do they acquire the ability to infect humans? Is it wholly dependent on “recognition” (a function typically mediated by protein-protein binding between viral capsid and target host cell), or must there be changes in other viral replication mechanisms as well? And specifically focusing on SARS-Cov-2, did it evolve to infect humans via many evolutionary changes or only a few? Was it dependent on a key functional shift in its ability to bind human cells, or is there evidence that other genomic changes were needed for it to acquire its strikingly high degree of infectivity? Answering these questions is critical if we are to understand both the origin of specific viruses, such as SARS-CoV-2, as well as the capacity of animal viruses to evolve human infectivity.SARS-CoV-2 emerged in late 201911 and has high infectivity, spreading rapidly around the world, causing a global health emergency.12 A member of the Coronaviridae family of polymorphic, enveloped, single stranded RNA viruses,13 it is thought that SARS-CoV-2 evolved from a zoonotic origin,14,15 owing to its clear evolutionary relationship with coronaviruses that have been isolated from animals16 (its closest known evolutionary relative is the bat coronavirus, RaTG1317–20 and the second-closest known relative is a pangolin coronavirus, Pangolin-CoV).21 While most of the SARS-CoV-2 genome is most similar to the RaTG13 genome, some genomic regions, including the Spike glycoprotein Receptor Binding Domain (RBD) (which mediates viral entry into host cells), have greater sequence similarity to the Pangolin-CoV homolog,22 prompting some to suggest SARS-CoV-2 may be the product of recombination during co-infection.21–24 The Spike protein is a key component of the SARS-CoV-2 infection pathway.25 Knockout and overexpression studies have demonstrated that binding of the Spike-RBD to human angiotensin converting enzyme 2 (hACE2) mediates cellular entry of SARS-CoV-2.26–30 The protein sequence of this surface receptor is variable, with particular rare variants increasing patient susceptibility to SARS-CoV-2 infection.31 The SARS-CoV-2 Spike protein has been shown to bind the hACE2 receptor with greater affinity than the SARS-CoV-1 homolog, which has been suggested as a possible explanation for its greater infectivity.29 Additionally, many other related coronaviruses have been shown to be unable to bind hACE2 with sufficient affinity to support infection, raising the possibility that high hACE2 is a recently acquired trait for SARS-CoV-2.32–34 Given this, a critical question remains to be answered: How and when did the SARS-CoV-2 Spike protein evolve its relatively higher affinity for the hACE2? With this question in mind, we set out to robustly characterize the evolutionary changes that accompanied the emergence of SARS-CoV-2, and that distinguish it from its closest zoonotic relatives. We focused on the evolution of the Spike-RBD by leveraging its known evolutionary relationships to other animal and human viruses and employed ancestral sequence reconstruction in conjunction with molecular dynamics simulations to identify biochemical and biophysical changes that enhanced Spike binding to the hACE2 receptor. Our initial phylogenetic analysis utilized whole viral genomic data, and generally supports prior studies’ conclusions, finding similar levels of nucleotide identity to the RaTG13 genome (96.0% sequence identity) and the Pangolin-CoV genome (90.0% sequence identity) (Supplementary Figure 1A).21,29 We next quantified the degree of evolutionary diversification that has occurred during SARS-CoV-2’s global spread. We performed an in-depth analysis of 479 sequences collected between December 30, 2019 and March 20, 2020, and observe 16 polymorphisms, including 11 missense mutations present in >5% of infections (Supplemental Table 1), each mapping to unique phylogenetic branches (Figure 1A). One monophyletic clade was primarily isolated within the United States and Canada, and is defined by two synapomorphic missense mutations: c.17848A>G and c.28134C>T.35 Since these occur in one of the most variable parts of the coronavirus genome, it is likely that its distribution is due to a founder effect and that it does not confer an evolutionary advantage.36 It is also worth noting that neither appears in the Spike protein-coding region, making it unlikely to impact hACE2 affinity.
View this table:
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Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - coronavirus immunity: Jain Farm Fresh launches immunity booster against Covid | ||
Sat, 27 Jun 2020 08:56:15 -0400 In a bid to boost immunity against Covid, Jain Farm Fresh Foods' brand Valley Spice has launched Aayush Kadha. The ingredients of this product are ... Google Alert - coronavirus immunity Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Epidemiology from Michael_Novakhov (39 sites): Google Alert - COVID-19 Outbreak In fish and seafood Industry: Quick-Frozen Food Market Future Growth by In Depth Industry Analysis, Size, Trends and Forecast ... | ||
Sat, 27 Jun 2020 08:56:15 -0400 Under COVID-19 Outbreak, how the Quick-Frozen Food Market will develop is also analyzed in detail in this report. ... The impact of COVID-19 on the future development of the industry is pointed out. ... Fish and Seafood Soup. Google Alert - COVID-19 Outbreak In fish and seafood Industry Disease X-19 Epidemiology from Michael_Novakhov (39 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - Covid-19 blood clots: Winderman: The only questions for the Heat, NBA . . . are the lingering questions | Commentary | ||
Sat, 27 Jun 2020 08:56:15 -0400 Like so much in these uncertain times, amid the coronavirus pandemic, there ... In the case of playing through a pandemic, a single shaky action with the ... James left for the Cleveland Cavaliers, Bosh succumbed to blood clots, and ... Google Alert - Covid-19 blood clots Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - Coronavirus by country, ethnicity, and race: A Q&A with Jim Gilmore, US ambassador to the Organization for Security and Cooperation in ... | ||
Sat, 27 Jun 2020 08:56:15 -0400 The OSCE region includes a very large number of countries, some old, and some newly ... This appeal to race and ethnicity leads to instability that can lead to conflict, actual ... Long before COVID-19, Europe was a dangerous place. Google Alert - Coronavirus by country, ethnicity, and race Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Symptoms from Michael_Novakhov (16 sites): Google Alert - coronavirus cardiac symptoms: India coronavirus dispatch: Long road to recovery for discharged patients | ||
Sat, 27 Jun 2020 08:45:00 -0400 ... cardiac problems now common signs during convalescence. Doctors across the city said apart from treating actively infected Covid-19 patients, ... Google Alert - coronavirus cardiac symptoms Disease X-19 Symptoms from Michael_Novakhov (16 sites) | ||
mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c | ||
Sat, 27 Jun 2020 06:51:07 -0400
SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c
mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c | ||
Sat, 27 Jun 2020 06:51:07 -0400
SARS-CoV-2 Traces Detected in Barcelona Waste Water From March 2019 | Technology Networks technologynetworks.com/tn/news/sars-c…
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @EpochOpinion: Opinion | ||
Sat, 27 Jun 2020 06:45:24 -0400
Opinion
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Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @EpochOpinion: Opinion | ||
Sat, 27 Jun 2020 06:45:24 -0400
OpinionðŸ’by Brian Cates @drawandstrike
New documents revealed a bombshell: both President @BarackObama and VP @JoeBiden were directly involved in the @FBI’s investigation of @GenFlynn. These notes demonstrate that #Obama and #Biden have been misleading. theepochtimes.com/notes-prove-ob…
221 likes, 128 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @DailyMailUK: Prince Charles 'foresaw problems' when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd | ||
Sat, 27 Jun 2020 06:44:48 -0400
Prince Charles 'foresaw problems' when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd
Retweeted by mikenov on Saturday, June 27th, 2020 10:44am
58 likes, 22 retweets mikenov on Twitter | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @DailyMailUK: Prince Charles foresaw problems when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd | ||
Sat, 27 Jun 2020 06:44:48 -0400
Prince Charles ‘foresaw problems’ when Meghan Markle joined the royal family, royal author claims trib.al/rK5JbTd
58 likes, 22 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @KremlinTrolls: THREAD: How @realDonaldTrump became Putin's most valuable asset: mobile.twitter.com/KremlinTrolls/ | ||
Sat, 27 Jun 2020 06:44:17 -0400
THREAD: How @realDonaldTrump became Putin's most valuable asset:
mobile.twitter.com/KremlinTrolls/
| ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @KremlinTrolls: THREAD: How @realDonaldTrump became Putins most valuable asset: mobile.twitter.com/KremlinTrolls/ | ||
Sat, 27 Jun 2020 06:44:17 -0400
THREAD: How @realDonaldTrump became Putin’s most valuable asset:
mobile.twitter.com/KremlinTrolls/…
15 likes, 12 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @NYPDDCPI: NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipet | ||
Sat, 27 Jun 2020 06:43:25 -0400
NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipetri discusses where the increase in gun violence originates and what can be done to end it.
Watch more via @FoxNews | ||
Covid-19 Review: The Pandemic As The Bio-Info-Weapon: mikenov on Twitter: RT @NYPDDCPI: NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipet | ||
Sat, 27 Jun 2020 06:43:25 -0400
NYC has seen 125 reported shootings in the first three weeks of June, more than double the same period last year. Chief Lipetri discusses where the increase in gun violence originates and what can be done to end it.
Watch more via @FoxNews 🔽 ow.ly/aoC850Aj68j
67 likes, 41 retweets
Covid-19 Review: The Pandemic As The Bio-Info-Weapon | ||
mikenov on Twitter: RT @QuizGriz: Fishermen Spot Animal Stuck On Iceberg. They Get Closer and Freeze When They See What It Really Is. | ||
Sat, 27 Jun 2020 06:42:58 -0400
Fishermen Spot Animal Stuck On Iceberg. They Get Closer and Freeze When They See What It Really Is.
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mikenov on Twitter: Germany Coronavirus Outbreak: Meat Plant Triggers Cases - Bloomberg bloomberg.com/news/articles/ | ||
Sat, 27 Jun 2020 06:42:11 -0400 mikenov on Twitter | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in iran: Coronavirus Cases in Iran Surpass 220000 | ||
Sat, 27 Jun 2020 06:30:00 -0400 Speaking at a daily press conference on Saturday, Sima Sadat Lari said the number of people tested positive for COVID-19 across the country has risen ... Google Alert - coronavirus in iran Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
Disease X-19 Regions from Michael_Novakhov (8 sites): Google Alert - coronavirus in iran: Iran reveals COVID-19 statistics for June 27 | ||
Sat, 27 Jun 2020 06:30:00 -0400 By Elnur Baghishov - Trend: As many as 2,456 people have been infected with the coronavirus (COVID-19) in the past 24 hours in Iran, said Sima Sadat ... Google Alert - coronavirus in iran Disease X-19 Regions from Michael_Novakhov (8 sites) | ||
mikenov on Twitter: Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought - The New York Times nytimes.com/2020/06/26/hea | ||
Sat, 27 Jun 2020 06:19:47 -0400
Study Suggests Coronavirus Emerged In Spain Much Earlier Than Thought - The New York Times nytimes.com/2020/06/26/hea
mikenov on Twitter | ||
mikenov on Twitter: Covid-19-Review: Coronavirus and US Military: As COVID-19 spikes across US, troop diagnoses jump 20 percent in a week | Coronavirus and HIV: How the Coronavirus Short-Circuits the Immune System covid-19-review.blogspot.com/2020/06/556- | ||
Sat, 27 Jun 2020 06:15:15 -0400
Covid-19-Review: Coronavirus and US Military: As COVID-19 spikes across US, troop diagnoses jump 20 percent in a week | Coronavirus and HIV: How the Coronavirus Short-Circuits the Immune System covid-19-review.blogspot.com/2020/06/556-am
mikenov on Twitter | ||
mikenov on Twitter: Covid-19-Review: 5:56 AM 6/27/2020 - Sars-Cov-2 as bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | Italy's Frontline: A Doctor's Diary shows stark reality of coronavirus crisis covid-19-review.blogspot.com/2020 | ||
Sat, 27 Jun 2020 06:14:32 -0400
Covid-19-Review: 5:56 AM 6/27/2020 - Sars-Cov-2 as bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | Italy's Frontline: A Doctor's Diary shows stark reality of coronavirus crisis covid-19-review.blogspot.com/2020/06/556-am
1 like mikenov on Twitter | ||
Michael Novakhov - SharedNewsLinks: 5:56 AM 6/27/2020 - Sars-Cov-2 as bioweapon: Is there any truth behind the Covid-19 conspiracy theories? | Italy's Frontline: A Doctor's Diary shows stark reality of coronavirus crisis | Coronavirus and US Military: As | ||
Sat, 27 Jun 2020 06:12:32 -0400
Disease X-19 as the Bio-weapon from Michael_Novakhov (3 sites): Google Alert - sars cov 2 as bioweapon: Is there any truth behind the Covid-19 conspiracy theories? 5:56 AM 6/27/2020 Coronavirus and US Military: As COVID-19 spikes across US, troop diagnoses jump 20 percent in a week
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