Covid-19 as the BIOWEAPON: Only the German - New Abwehr (Military?) Microbiologists have the capability to construct this Covid-19 Bio-weapon & to use it together with Information warfare, & in the most sophisticated way. The Chinese and the Russians, and others (?Israelis), are just the covers, as always. Sars and AIDS are the Bioweapons, and constructed by the New Abwehr researchers also! - M.N. | This is an Accepted Manuscript for QRB Discovery as part of... | Sir Richard Dearlove said there was good evidence that the virus was engineered, but that it's escape from the laboratory was accidental. | RT @LawrenceSellin: The time is long overdue for U.S. intelligence agencies to reassess their statement that the #COVID19 virus is naturall… - 9:17 AM 6/5/2020
M.N.: The second and the main part is true, I think: NO ABILITY!
Coronavirus origin still unclear as China lab rejects conspiracy theories - The Jerusalem Post jpost.com/international/ …
Subject to change during the editing and production process.
A Candidate Vaccine for Covid-19 (SARS-CoV-2) Developed from Analysis of its General Method of Action for
B. Sørensen(1), A. Susrud(1), A.G.Dalgleish(2)
1) Immunor AS, Oslo, Norway
2) Foundation Professor of Oncology, St. George's, University of London, Institute of Infection and Immunity, London,
This study presents the background, rationale and Method of Action of Biovacc-19, a candidate vaccine for Covid-19,
now in advanced pre-clinical development, which has already passed the first acute toxicity testing. Unlike
conventionally developed vaccines, Biovacc-19's Method of Operation is upon non human-like (NHL) epitopes in
21.6% of the composition of SARS-CoV-2's Spike protein, which displays distinct distributed charge including the
presence of a charged furin-like cleavage site. The logic of the design of the vaccine is explained, which starts with
empirical analysis of the aetiology of SARS-CoV-2. Mistaken assumptions about SARS-CoV-2's aetiology risk
creating ineffective or actively harmful vaccines, including the risk of Antibody-Dependent Enhancement (ADE). Such
problems in vaccine design are illustrated from past experience in the HIV domain. We propose that the dual effect
general method of action of this chimeric virus’s spike, including receptor binding domain, includes membrane
components other than the ACE2 receptor, which explains clinical evidence of its infectivity and pathogenicity. We
show the non-receptor dependent phagocytic general method of action to be specifically related to cumulative charge
from inserted sections placed on the SARS-CoV-2 Spike surface in positions to bind efficiently by salt bridge
formations; and from blasting the Spike we display the non human-like epitopes from which Biovacc-19 has been
May 28, 2020 - Author Contributions. Birger Sørensen: Writing original draft. Angus Dalgleish: Review and editing. Andres Susrud: Investigation and Review ...
Fig. 2. The identified inserts examined in the PDB 6VXX electron microscopy structure (Walls et al., 2020) The
sequences highlighted in red could not be found in the cryo-electron microscopy structure data. The 6 aligned
sequences in Fig. 1 are underlined in the missing sequences. Bold amino acids indicate first and last amino acids
used to build the structure where the missing part is in between. Insert 6 did not have the same sequence in 6VXX as
in the reference Sars-CoV-2 sequence. The authors stated that a designed mutated strain lacking the furin cleavage
site residues was used.
Our findings confirm (Coutard et al., 2020) that the SARS-CoV-2 contains a furin-like cleavage site absent in CoV of the same clade. Also in Fig 1, Coutard highlight that enriched basic charge associated with this cleavage site are found in a number of viruses such as Human Immunodeficiency Viruses, Influenza, human CytoMegalo Virus (Herpes) and Respiratory Syncytial Virus, Yellow fever, Zika and Ebola. Coutard et al furthermore state that, "conversely, the highly pathogenic forms of influenza have a furin-like cleavage site cleaved by different cellular proteases, including furin, which are expressed in a wide variety of cell types allowing a widening of the cell tropism of the virus." Furthermore the insertion of a multibasic motif RERRRKKR↓GL at the H5N1 hemagglutinin HA cleavage site was likely associated with the hyper-virulence of the virus during the Hong Kong 1997 outbreak. Extensive clinical evidence in this pandemic suggests that SARS-CoV-2 poses such widened cell tropism. The mechanism of action linked to such basic Arginine rich domains is known as the binding of cell-penetrating peptides (Thorén et al., 2000). The important point to grasp is that such positively charged amino acids need to be located in such a way that they span four amino acids (or more) in length to act as an initial membrane anchor. Use of such positive charged vaccine peptides allows for attachment and/or direct cell uptake depending on the net charge present in the peptide (Åmand et al., 2011; US patent – US9950811B2n). The present authors have used such basic properties in uploading vaccine peptides to cells (typically macrophages and dendritic cells). We have found that more than 3 Arginines are required for uptake. In addition this charge needs to be distributed over the peptide. (Yesylevskyy et al., 2009). Fig. 3 (a-f) illustrate the process in dynamic sequence from attachment to cell membrane until complete cell penetration.
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