The clinical picture of altered coagulation in several viral infections manifests itself in bleeding (hemorrhage), thrombosis, or both. - 10:40 AM 5/23/2020
Viral infections and mechanisms of thrombosis and bleeding
williams.medicine.wisc.edu › viral_coagulopathy_2012
Crimean-Congo hemorrhagic fever [Geisbert and ... found among viral hemorrhagic fever infections, as ... other factors, such as thrombophilia as a host factor.
by M Goeijenbier - 2012 - Cited by 58 - Related articles
Viral infections are associated with coagulation disorders. As a consequence, thrombosis and disseminated intravascular coagulation, hemorrhage, or both, may occur.
Review: Viral Infections and Mechanisms of Thrombosis and ...
Inflammation impacts the initiation, propagation and inhibitory phases of blood coagulation [Opal, 2003]. In viral and bacterial infections, this can actually lead to both thrombotic as well as hemorrhagic complications. Pathogens, as well as inflammatory cells and mediators, can induce the expression of tissue factor on monocytes and endothelial cell surfaces. Tissue factor is a major activator of coagulation [Van der Poll et al., 2011]. Direct or indirect activation of the endothelium by viruses or other pathogens may result in alterations in the coagulation and the fibrinolytic systems [van Gorp et al., 1999]. Normally, coagulation is a balance between procoagulant and (natural) anticoagulant mechanisms. A regulated activation of coagulation is part of the host’s defence against infectious agents [Opal, 2003]. Inflammation may lead to altered coagulation, resulting in an imbalance between the pro- and anticoagulant state. The clinical picture of altered coagulation in several viral infections manifests itself in bleeding (hemorrhage), thrombosis, or both. An exaggerated response may even lead to disseminated intravascular coagulation with the formation of microvascular thrombi in various organs [Levi, 2007]. Disseminated intravascular coagulation contributes to multiple organ failure and is associated with high mortality in both bacterial and nonbacterial diseases [Levi et al., 2004; Levi, 2007]. Other syndromes associated with bacterial or viral infections...
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