Hypercoagulability in Hemorrhagic Fevers: Venous thromboembolism following hemorrhagic fever - Connolly-Andersen - 9:56 AM 5/23/2020
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https://covid-19-review.blogspot.com/2020/05/hypercoagulability-in-hemorrhagic.html
- hypercoagulability in hemorrhagic fevers - Google Search
venous thromboembolism following hemorrhagic fever … - Connolly-Andersen - Cited by 7https://www.google.com/search?q=hypercoagulability+in+hemorrhagic+fevers&rlz=1C1CHBF_enUS733US733&oq=hypercoagulability+in+hemorrhagic+fevers&aqs=chrome..69i57j33.17869j0j7&sourceid=chrome&ie=UTF-8 … - However, the risk for thromboembolism following these viral hemorrhagic fevers has yet to be determined and quantified. https://academic.oup.com/cid/article/66/2/268/4103081 …
- case reports of 2 other Ebola virus–infected patients indicated a hypercoagulable phase following infection that warranted treatment with low-molecular-weight heparin [23]. https://academic.oup.com/cid/article/66/2/268/4103081 …
- increased von Willebrand factor levels in patients with hemorrhagic manifestations following infection with Sudan ebolavirus led to speculation that these patients have excessive thrombosis [22]. https://academic.oup.com/cid/article/66/2/268/4103081 …
- Concerning other viral hemorrhagic fevers, case reports for dengue virus indicate a similar tendency for VTE that we observed in our study [21]. Also, thrombosis is relevant for the outcome in viral hemorrhagic fever https://academic.oup.com/cid/article/66/2/268/4103081 …
- endothelial cells are affected during hantaviral infection regardless of their location [9]. Thereby, there are several mechanisms during hantavirus infection that could explain the increased risk for thromboembolism https://academic.oup.com/cid/article/66/2/268/4103081 …
- hantaviruses target endothelial cells during infection, resulting in increased coagulation and platelet adhesion [20]. Furthermore, the increased risk for arterial and venous thromboembolism during HFRS https://academic.oup.com/cid/article/66/2/268/4103081 …
- Endothelial cells are a key player in VHF pathogenesis and clinical outcome [19], and hantaviruses target endothelial cells during infection, resulting in increased coagulation and platelet adhesion [20]. https://academic.oup.com/cid/article/66/2/268/4103081 …
- Notably, we observe in our study of HFRS patients a much higher risk for DVT (approximately 46-fold) and PE (approximately 73-fold) in the same period https://academic.oup.com/cid/article/66/2/268/4103081 …
- This study of all Swedish HFRS patients from 1997 to 2014 shows an increased risk for VTE following a viral hemorrhagic fever. We previously identified HFRS as a risk factor for AMI and stroke [9]. https://academic.oup.com/cid/article/66/2/268/4103081 …
- A significantly increased risk for VTE was found in the time period following HFRS onset. It is important to keep this in mind and monitor HFRS patients, and possibly other viral hemorrhagic fever patients, for early symptoms of VTE. https://academic.oup.com/cid/article/66/2/268/4103081 …
- Why do some COVID-19 patients infect many others, whereas most don’t spread the virus at all? https://www.sciencemag.org/news/2020/05/why-do-some-covid-19-patients-infect-many-others-whereas-most-don-t-spread-virus-all …
- Covid-19: Syndrome of systemic coagulopathy, acquired thrombophilia, multiorgan thrombosis:
1. COVID-19 update: Covid-19-associated coagulopathy - NCBI
2. COVID-19 and Coagulopathy - http://Hematology.org
Google Search https://www.google.com/search?newwindow=1&rlz=1C1CHBF_enUS733US733&sxsrf=ALeKk03MxKTjkzG-eL01S_GM2z5tQICX2A%3A1590178661599&ei=ZTPIXrOPJMCCytMPl8KL8Ag&q=Covid-19%3A+Syndrome+of+systemic+coagulopathy%2C+acquired+thrombophilia%2C+multiorgan+thrombosis&oq=Covid-19%3A+Syndrome+of+systemic+coagulopathy%2C+acquired+thrombophilia%2C+multiorgan+thrombosis&gs_lcp=CgZwc3ktYWIQDDoECCEQClDD0w9YlL0RYLjwEWgAcAB4AIABggKIAb0ekgEGMC4xOC40mAEAoAEBqgEHZ3dzLXdpeg&sclient=psy-ab&ved=0ahUKEwjz1YOSpcjpAhVAgXIEHRfhAo4Q4dUDCAw … - he likely multifactorial origin of the activation and the increasing evidence for the importance of cellular elements or their derived microparticles https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770956/ …
- Despite longstanding evidence for increased activation of coagulation in hemolytic anemias, its pathophysiology and its role in the vaso-occlusive crises of sickle disease remain unclear. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770956/ …
- TRUMP IS SUICIDAL:
Covid-19 in the US: Hydroxychloroquine treatment for Covid-19 linked to a greater risk of death, study finds - CNN https://www.cnn.com/2020/05/22/health/us-coronavirus-friday/index.html … - Covid-19 differential diagnosis - Google Search https://www.google.com/search?q=Covid-19+differential+diagnosis&newwindow=1&rlz=1C1CHBF_enUS733US733&sxsrf=ALeKk02oCq-noLbLd4lHSIg8uW0GwKJMoQ%3A1590168368019&source=lnms&tbm=nws&sa=X&ved=2ahUKEwidttXl_sfpAhXzknIEHfuXCgUQ_AUoA3oECBUQBQ&biw=1536&bih=722 …
- Histologic analysis of pulmonary vessels in patients with Covid-19 showed widespread thrombosis with microangiopathy. Alveolar capillary microthrombi were 9 times as prevalent in patients with Covid-19 as in patients with influenza (P<0.001). https://www.nejm.org/doi/full/10.1056/NEJMoa2015432 …
- #Covid19 #symptoms are complex, polymorphous, multi-systems, multi-organs; with underlying #coagulopathies and #thromboses. https://covid-19-review.blogspot.com/2020/05/1201-pm-5222020-michael-novakhov.html?spref=tw …
- News - COVID-19 update: Covid-19-associated coagulopathy - Google Search https://www.google.com/search?q=COVID-19+update%3A+Covid-19-associated+coagulopathy&newwindow=1&rlz=1C1CHBF_enUS733US733&hl=en&tbm=nws&sxsrf=ALeKk00x25xowpoWiHU5p42rkDqWW1rs4w%3A1590162594934&source=lnt&tbs=sbd%3A1&sa=X&ved=0ahUKEwjqnuyk6cfpAhXql3IEHScIAbYQpwUIIw&biw=1536&bih=722&dpr=1.25 …
- Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 | NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2015432 …
- the relevance of COVID-19-coagulation abnormalities are becoming increasingly clear as a substantial proportion of patients with severe COVID-19 develop, sometimes unrecognised, venous and arterial thromboembolic complications. https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(20)30145-9/fulltext …
- Coagulation abnormalities and thrombosis in patients with COVID-19 https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(20)30145-9/fulltext#.Xsf0yQsow_8.twitter …
- COVID-19 and Coagulopathy - http://Hematology.org https://www.hematology.org/covid-19/covid-19-and-coagulopathy …
- Covid-19 symptoms include blood clots, organ failure - CNN https://www.cnn.com/2020/05/12/health/coronavirus-symptoms-blood-clots-inflammation/index.html …
- Covid-19 symptoms are complex, polymorphous, multi-systems, multi-organs; with underlying coagulopathies and thromboses https://images.app.goo.gl/jLZg8g3gPZDorg497 …
- COVID-19 update: Covid-19-associated coagulopathy - Google Search https://www.google.com/search?q=COVID-19+update%3A+Covid-19-associated+coagulopathy&source=lmns&bih=722&biw=1536&rlz=1C1CHBF_enUS733US733&hl=en&ved=2ahUKEwin26rU58fpAhUGSN8KHcc4CR4Q_AUoAHoECAEQAA …
- Covid-19 symptoms are complex, polymorphous, multi-systems, multi-organs; with underlying coagulopathies and thromboses https://images.app.goo.gl/hXee7PVqQWi9A41F7 …
- Covid-19 symptoms are complex, polymorphous, multi-systems, multi-organs; with underlying coagulopathies and thromboses - Google Search https://www.google.com/search?q=Covid-19+symptoms+are+complex%2C+polymorphous%2C+multi-systems%2C+multi-organs%3B+with+underlying+coagulopathies+and+thromboses&newwindow=1&rlz=1C1CHBF_enUS733US733&sxsrf=ALeKk02WwI8Ybms0PIS0i6Nznd7JS-r_-Q%3A1590160609161&source=lnms&tbm=isch&sa=X&ved=2ahUKEwi-q_rx4cfpAhXimHIEHb0OAxMQ_AUoAnoECBUQBA&biw=1536&bih=722#imgrc=2ugl3tU-_NXX3M …
- Covid-19 symptoms are complex, polymorphous, multi-systems, multi-organs; with underlying coagulopathies and thromboses
https://images.app.goo.gl/fcjEMUeqTKjeXhEg8 … - An acquired syndrome known as Covid-19-associated coagulopathy has emerged and proven itself to be common, multifactorial with involvement of the venous, arterial and microcirculatory systems and distinct from other viral illnesses. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225095/ …
- chest CT findings of bilateral patchy infiltrates and a “ground glass” pattern, coupled with biopsy and autopsy findings raise an important question about the lungs as a primary source of Covid-19- associated coagulopathy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225095/ …
- The Covid-19 pandemic has introduced an array of organ-specific and systemic phenotypes- some previously observed in viral infections, including severe acute respiratory syndrome (SARS) and others that appear to be unique to SARS-coronavirus (CoV)-2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225095/ …
- ...mechanism(s) underlying the development of a systemic coagulopathy and acquired thrombophilia characterized in a majority of cases by a proclivity for venous, arterial and microvascular thrombosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225095/ …
- COVID-19 update: Covid-19-associated coagulopathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225095/ …
- CDC says 35% of coronavirus infections are asymptomatic - CNN https://www.cnn.com/2020/05/22/health/cdc-coronavirus-estimates-symptoms-deaths/index.html …
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